Purines play an integral role in cellular processes such as energy metabolism, cell signaling
and encoding the genetic makeup of all living organisms—ensuring that the purine …

Ureides are a class of cyclic or acyclic nitrogenous organic compounds derived from or
structurally related to urea. Representatives of this class which have been found in plants …

Stress response helps microorganisms survive extreme environmental conditions and host
immunity, making them more virulent or drug resistant. Although both reductionist …

We review literature on the metabolism of ribo-and deoxyribonucleotides, nucleosides, and
nucleobases in Escherichia coli and Salmonella, including biosynthesis, degradation …

Glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase from Escherichia coli
exhibits a basal PRPP-independent glutaminase activity having ak cat/K m that is 0.3% of …

A family of four glutamine amidotransferases has a homologous glutamine amide transfer
domain, designated purF-type, that is named after purF-encoded glutamine …

Crystal structures of glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase
from Escherichia coli have been determined to 2.0‐Å resolution in the absence of ligands …

Summary Inosine 5′‐monophosphate dehydrogenase (IMPDH) catalyses the rate‐limiting
step in guanine nucleotide biosynthesis. IMPDH has an evolutionary conserved CBS …

Comparison of the primary structures of three phosphoribosyltransferases (human
hypoxanthine-guanine, Salmonella typhimurium ATP, and Escherichia coli glutamine) …

Recent studies of glutamine PRPP amidotransferase have provided a new understanding of
the function and mechanism of this rather complicated enzyme that may be a paradigm for …