L-(alphaS, 5S)-alpha-Amino-3-chloro-4, 5-dihydro-5-isoxazoleacetic acid (AT-125), an
antitumor drug isolated from Streptomyces sviceus, is an active site-directed affinity analog …

Bacillus subtilis glutamine P-Rib-PP amidotransferase contains a [4Fe-4S] cluster which is
essential for activity. The enzyme also undergoes removal of 11 NH 2-terminal residues from …

Deriving new value from waste streams through secondary processes is a central aim of the
circular bioeconomy. In this study we investigate whether chemically defined spent media …

The yeast transcriptional regulator protein GCN4 harbors the bZIP DNA binding motif, which
is common to a family of DNA-binding proteins in eukaryotic organisms from yeast to man …

In Salmonella typhimurium, the synthesis of the pyrimidine moiety of thiamine can occur by
utilization of the first five steps in de novo purine biosynthesis or independently of the pur …

Metabolic aberrations, notably deviations in glutamine metabolism, are crucial in the
oncogenic process, offering vital resources for the unlimited proliferation and enhanced …

The prevalence of paralogous enzymes implies that novel catalytic functions can evolve on
preexisting protein scaffolds. The weak secondary activities of proteins, which reflect …

Glutamine 5-phosphoribosylamine pyrophosphate phosphoribosyltransferase (
amidophosphoribosyltransferase) was purified in large amounts from an Escherichia coli …

Glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase catalyzes the first
reaction of de novopurine nucleotide synthesis in two steps at two sites. Glutamine is …

Glutamine 5-phosphoribosylpyrophosphate amidotransferase from Escherichia coli is
subject to synergistic feedback regulation by adenine and guanine nucleotides. Inhibition …