Background The cyclin-dependent kinase 7 (CDK7) subunit of TFIIH regulates RNA
polymerase-II-based transcription and promotes tumor progression. However, the …

Childhood cancer is considered rare, corresponding to~ 3% of all malignant neoplasms in
the human population. The World Health Organization (WHO) reports a universal …

Recently, due to the limitations of cell line models and animal models in the preclinical
research with insufficient reflecting the physiological situation of humans, patient-derived …

Purpose We aimed to inhibit ovarian cancer (OC) development by interfering with
microtubule polymerization and inhibiting mTOR signaling. To achieve this, previously …

The cyclin-dependent kinase 7 (CDK7) plays a crucial role in regulating the cell cycle and
RNA polymerase-based transcription. Overexpression of this kinase is linked with various …

NANOG engages with tumour initiation and metastasis by regulating the epithelial–
mesenchymal transition (EMT) in epithelial ovarian cancer (EOC). However, its role in …

Background Cyclin-dependent kinase 7 (CDK7) is crucial for cell cycle progression and
gene expression transcriptional regulation, which are often not assessed in cancer …

DNA repair pathways are essential for maintaining genome stability, and understanding the
regulation of these mechanisms may help in the design of new strategies for treatments, the …

Background Ovarian cancer (OC) is amongst the most lethal of common cancers in women.
Lacking in specific symptoms in the early stages, OC is predominantly diagnosed late when …

Background: Overexpression of cyclin-dependent kinase 7 (CDK7) is a well-known
pathogenic feature of various malignancies and a sign of a more dismal prognosis. As …