The emerging era of cell engineering: Harnessing the modularity of cells to program complex biological function

WA Lim - Science, 2022 - science.org
A new era of biological engineering is emerging in which living cells are used as building
blocks to address therapeutic challenges. These efforts are distinct from traditional …

Engineering cells for precision drug delivery: New advances, clinical translation, and emerging strategies

CJ Chao, E Zhang, Z Zhao - Advanced Drug Delivery Reviews, 2023 - Elsevier
Cells have emerged as a promising new form of drug delivery carriers owing to their
distinguished advantages such as naturally bypassing immune recognition, intrinsic …

Nanoparticle‐Based Photothermal Therapy for Breast Cancer Noninvasive Treatment

Y Xiong, Y Rao, J Hu, Z Luo, C Chen - Advanced materials, 2023 - Wiley Online Library
Rapid advancements in materials science and nanotechnology, intertwined with oncology,
have positioned photothermal therapy (PTT) as a promising noninvasive treatment strategy …

Bacteria‐Based Backpacks to Enhance Adoptive Macrophage Transfer against Solid Tumors

JX An, ZY Han, YT Qin, CX Li, JL He… - Advanced …, 2024 - Wiley Online Library
Adoptive cell therapy has emerged as a promising approach for cancer treatment. However,
the transfer of macrophages exhibits limited efficacy against solid tumors due to the dynamic …

Upconversion dual-photosensitizer–expressing bacteria for near-infrared monochromatically excitable synergistic phototherapy

M Chen, Q Han, M Zhang, Y Liu, L Wang, F Yang… - Science …, 2024 - science.org
Synergistic phototherapy stands for superior treatment prospects than a single
phototherapeutic modality. However, the combined photosensitizers often suffer from …

Decoding the microbiome: advances in genetic manipulation for gut bacteria

Z Chen, W Jin, A Hoover, Y Chao, Y Ma - Trends in Microbiology, 2023 - cell.com
Studies of the gut microbiota have revealed associations between specific bacterial species
or community compositions with health and disease, yet the causal mechanisms underlying …

Engineered living materials for advanced diseases therapy

X Dong, W Wu, P Pan, XZ Zhang - Advanced Materials, 2023 - Wiley Online Library
Natural living materials serving as biotherapeutics exhibit great potential for treating various
diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this …

Bioengineering of bacteria for cancer immunotherapy

DH Nguyen, A Chong, Y Hong, JJ Min - nature communications, 2023 - nature.com
Here, we provide a brief overview of the approaches and strategies underlying bacteria-
based cancer immunotherapy (BCiT). We also describe and summarize research in the field …

Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia

CR Gurbatri, GA Radford, L Vrbanac, J Im… - Nature …, 2024 - nature.com
Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC)
screening, prevention and treatment. Here, first, we demonstrate selective colonization of …

Micro-engineering and nano-engineering approaches to investigate tumour ecosystems

M Kim, M Panagiotakopoulou, C Chen, SB Ruiz… - Nature Reviews …, 2023 - nature.com
The interactions among tumour cells, the tumour microenvironment (TME) and non-tumour
tissues are of interest to many cancer researchers. Micro-engineering approaches and …