Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Aims Over the past years, interest in chrono-nutrition has grown enormously as the
fundamental role of circadian rhythms in regulating most physiological and metabolic …

As the thymus involutes during aging, the T‐cell pool has to be maintained by the periodic
expansion of preexisting T cells during adulthood. A conundrum is that repeated episodes of …

Circadian clocks control the internal sleep-wake rhythmicity of 24 h which is synchronized by
the solar cycle. Circadian regulation of metabolism evolved about 2.5 billion years ago, ie …

Aging is a multifunctional physiological manifestation. The nasal cavity is considered a
major site for easy and cost-effective drug and vaccine administration, due to high …

Cellular senescence and chronic inflammation in response to aging are considered to be
indicators of brain aging; they have a great impact on the aging process and are the main …

Obesity is a worldwide trend that is growing in incidence very fast. Adipose tissue
dysfunction caused by obesity is associated with the generation of oxidative stress. Obesity …

FOXO3 is a member of the FOXO transcription factor family and is known for regulating
cellular survival in response to stress caused by various external and biological stimuli …

The circadian clock system orchestrates daily behavioral and physiological rhythms,
facilitating adaptation to environmental and internal oscillations. Disruptions in circadian …

(1) Background: Numerous elements of the Mediterranean diet (MD) have antioxidant and
anti-inflammatory qualities.(2) Methods: We present a narrative review of the potential …