Single-cell RNA sequencing (scRNA-seq) allows researchers to collect large catalogues
detailing the transcriptomes of individual cells. Unsupervised clustering is of central …

Animal behavior is shaped by a variety of" internal states"—partially hidden variables that
profoundly shape perception, cognition, and action. The neural basis of internal states, such …

The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) involves a
significant accumulation of fibroblasts as part of the host response to cancer. Using single …

The hypothalamus plays a key role in coordinating fundamental body functions. Despite
recent progress in single-cell technologies, a unified catalog and molecular characterization …

Dimension reduction (DR) techniques such as t-SNE, UMAP, and TriMap have
demonstrated impressive visualization performance on many real-world datasets. One …

The mammalian brain is complex, with multiple cell types performing a variety of diverse
functions, but exactly how each cell type is affected in aging remains largely unknown. Here …

INTRODUCTION A mechanistic understanding of brain function requires the identification of
distinct cell types in the brain at a molecular, spatial, and functional level. The preoptic …

UMAP (Uniform Manifold Approximation and Projection) is a novel manifold learning
technique for dimension reduction. UMAP is constructed from a theoretical framework based …

In the past decade, single-cell technologies have proliferated and improved from their
technically challenging beginnings to become common laboratory methods capable of …

The neocortex contains a multitude of cell types that are segregated into layers and
functionally distinct areas. To investigate the diversity of cell types across the mouse …