COVID-19 and the vasculature: current aspects and long-term consequences

B Martinez-Salazar, M Holwerda, C Stuedle… - Frontiers in cell and …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was first identified in
December 2019 as a novel respiratory pathogen and is the causative agent of Corona Virus …

Long-term effect of SARS-CoV-2 infection on cardiovascular outcomes and all-cause mortality

A Aleksova, AL Fluca, G Gagno, A Pierri, L Padoan… - Life sciences, 2022 - Elsevier
Since the very beginning of the coronavirus disease 2019 (COVID-19) pandemic in early
2020, it was evident that patients with cardiovascular disease (CVD) were at an increased …

Cell-specific mechanisms in the heart of COVID-19 patients

EJ Tsai, D Čiháková, NR Tucker - Circulation research, 2023 - Am Heart Assoc
From the onset of the pandemic, evidence of cardiac involvement in acute COVID-19
abounded. Cardiac presentations ranged from arrhythmias to ischemia, myopericarditis …

MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation

MG Noval, SN Spector, E Bartnicki, F Izzo… - Nature …, 2023 - nature.com
Chikungunya virus (CHIKV) infection has been associated with severe cardiac
manifestations, yet, how CHIKV infection leads to heart disease remains unknown. Here, we …

Using autopsies to dissect COVID-19 pathogenesis

F Heinrich, KD Mertz, M Glatzel, M Beer… - Nature …, 2023 - nature.com
The emergence of SARS-CoV-2 has resulted in millions of deaths as a result of COVID-19.
Suitable models were missing at the beginning of the pandemic, and studies investigating …

Spatiotemporal transcriptomics reveals pathogenesis of viral myocarditis

M Mantri, MM Hinchman, DW McKellar… - Nature cardiovascular …, 2022 - nature.com
A significant fraction of sudden death in children and young adults is due to viral myocarditis,
an inflammatory disease of the heart. In this study, by using integrated single-cell and spatial …

How does COVID-19 affect the heart?

LR Sewanan, KJ Clerkin, NR Tucker… - Current Cardiology Reports, 2023 - Springer
Abstract Purpose of Review Cardiac consequences occur in both acute COVID-19 and post-
acute sequelae of COVID-19 (PASC). Here, we highlight the current understanding about …

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis

J Zhu, G Wang, X Huang, H Lee, JG Lee… - Communications …, 2022 - nature.com
SARS-CoV-2 infection causes COVID-19, a severe acute respiratory disease associated
with cardiovascular complications including long-term outcomes. The presence of virus in …

Human cardiac organoids to model COVID‐19 cytokine storm induced cardiac injuries

DC Arhontoulis, CM Kerr, D Richards… - Journal of Tissue …, 2022 - Wiley Online Library
Acute cardiac injuries occur in 20%–25% of hospitalized COVID‐19 patients. Herein, we
demonstrate that human cardiac organoids (hCOs) are a viable platform to model the …

The tissue-specific transcriptional landscape underlines the involvement of endothelial cells in health and disease

S Parab, E Setten, E Astanina, F Bussolino… - Pharmacology & …, 2023 - Elsevier
Endothelial cells (ECs) that line vascular and lymphatic vessels are being increasingly
recognized as important to organ function in health and disease. ECs participate not only in …