Macrophages in immunoregulation and therapeutics

S Chen, AFUH Saeed, Q Liu, Q Jiang, H Xu… - … and Targeted Therapy, 2023 - nature.com
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …

Macrophage-mediated inflammation in skin wound healing

A Hassanshahi, M Moradzad, S Ghalamkari, M Fadaei… - Cells, 2022 - mdpi.com
Macrophages are key immune cells that respond to infections, and modulate
pathophysiological conditions such as wound healing. By possessing phagocytic activities …

Roles of macrophage polarization and macrophage-derived miRNAs in pulmonary fibrosis

A Kishore, M Petrek - Frontiers in immunology, 2021 - frontiersin.org
This mini-review summarizes the current evidence for the role of macrophage activation and
polarization in inflammation and immune response pertinent to interstitial lung disease …

The role of macrophages in acute and chronic wound healing and interventions to promote pro-wound healing phenotypes

P Krzyszczyk, R Schloss, A Palmer… - Frontiers in …, 2018 - frontiersin.org
Macrophages play key roles in all phases of adult wound healing, which are inflammation,
proliferation, and remodeling. As wounds heal, the local macrophage population transitions …

Implications of macrophage polarization in autoimmunity

SC Funes, M Rios, J Escobar‐Vera, AM Kalergis - Immunology, 2018 - Wiley Online Library
Macrophages are extremely heterogeneous and plastic cells with an important role not only
in physiological conditions, but also during inflammation (both for initiation and resolution) …

Metabolically engineered stem cell–derived exosomes to regulate macrophage heterogeneity in rheumatoid arthritis

DG You, GT Lim, S Kwon, W Um, BH Oh, SH Song… - Science …, 2021 - science.org
Despite the remarkable advances in therapeutics for rheumatoid arthritis (RA), a large
number of patients still lack effective countermeasures. Recently, the reprogramming of …

DNA vaccines—how far from clinical use?

D Hobernik, M Bros - International journal of molecular sciences, 2018 - mdpi.com
Two decades ago successful transfection of antigen presenting cells (APC) in vivo was
demonstrated which resulted in the induction of primary adaptive immune responses. Due to …

MicroRNA delivery through nanoparticles

SWL Lee, C Paoletti, M Campisi, T Osaki… - Journal of Controlled …, 2019 - Elsevier
MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to
their central role in the etiology of major diseases. On the other hand, nanoparticle carriers …

Exosome-encapsulated miRNAs contribute to CXCL12/CXCR4-induced liver metastasis of colorectal cancer by enhancing M2 polarization of macrophages

D Wang, X Wang, M Si, J Yang, S Sun, H Wu, S Cui… - Cancer letters, 2020 - Elsevier
Tumor-associated macrophages (TAMs) are important immunocytes associated with cancer
metastasis. However, whether TAMs play a dominant role in mediating CXCL12/CXCR4 …

M1 macrophage-derived nanovesicles potentiate the anticancer efficacy of immune checkpoint inhibitors

YW Choo, M Kang, HY Kim, J Han, S Kang, JR Lee… - ACS …, 2018 - ACS Publications
Cancer immunotherapy modulates immune cells to induce antitumor immune responses.
Tumors employ immune checkpoints to evade immune cell attacks. Immune checkpoint …