Advancing pathogen genomics in resource-limited settings

PM Pronyk, R de Alwis, R Rockett, K Basile… - Cell Genomics, 2023 - cell.com
Genomic sequencing has emerged as a powerful tool to enhance early pathogen detection
and characterization with implications for public health and clinical decision making …

Review of dengue, zika and chikungunya infections in nervous system in endemic areas

M Puccioni-Sohler, CN Soares, PP Christo… - Arquivos de neuro …, 2023 - SciELO Brasil
Dengue, zika, and chikungunya are arboviruses of great epidemiological relevance
worldwide. The emergence and re-emergence of viral infections transmitted by mosquitoes …

Dengue virus infection and neurological manifestations: an update

SL Fong, KT Wong, CT Tan - Brain, 2024 - academic.oup.com
Dengue virus is a flavivirus transmitted by the mosquitoes, Aedes aegypti and Aedes
albopictus. Dengue infection by all four serotypes (DEN 1 to 4) is endemic globally in …

Dengue virus pathogenesis and host molecular machineries

S Sinha, K Singh, YS Ravi Kumar, R Roy… - Journal of Biomedical …, 2024 - Springer
Dengue viruses (DENV) are positive-stranded RNA viruses belonging to the Flaviviridae
family. DENV is the causative agent of dengue, the most rapidly spreading viral disease …

Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor

B Kesteleyn, JF Bonfanti, D Bardiot… - Journal of Medicinal …, 2024 - ACS Publications
Dengue is a global public health threat, with about half of the world's population at risk of
contracting this mosquito-borne viral disease. Climate change, urbanization, and global …

Multiple receptor tyrosine kinases regulate dengue infection of hepatocytes

NM Bourgeois, L Wei, NNT Ho, ML Neal… - Frontiers in Cellular …, 2024 - frontiersin.org
Introduction Dengue is an arboviral disease causing severe illness in over 500,000 people
each year. Currently, there is no way to constrain dengue in the clinic. Host kinase …

[HTML][HTML] An Insight into the Success, Challenges, and Future Perspectives of Eliminating Neglected Tropical Disease

SA Hudu, AO Jimoh, KA Adeshina, EG Otalike, A Tahir… - Scientific African, 2024 - Elsevier
Abstract Neglected Tropical Diseases (NTDs) are debilitating, chronic illnesses that have the
power to prolong poverty due to their negative effects on productivity, child development …

[HTML][HTML] Nicotiana benthamiana as a potential source for producing anti-dengue virus D54 neutralizing therapeutic antibody

S Krittanai, K Rattanapisit, CJI Bulaon… - Biotechnology …, 2024 - Elsevier
Dengue virus (DENV), transmitted by mosquitoes, is classified into four serotypes (DENV1-
4) and typically causes mild, self-limiting symptoms upon initial infection. However …

Dengue vaccination: towards a new dawn of curbing dengue infection

S Jain, N Vimal, N Angmo, M Sengupta… - Immunological …, 2023 - Taylor & Francis
Dengue is an infectious disease caused by dengue virus (DENV) and is a serious global
burden. Antibody-dependent enhancement and the ability of DENV to infect immune cells …

Identification of novel and potential inhibitors against the dengue virus NS2B/NS3 protease using virtual screening and biomolecular simulations

A Nasir, A Samad, A Ajmal, P Li, M Islam… - International Journal of …, 2024 - Elsevier
Approximately 3.9 billion individuals are vulnerable to dengue infection, a prevalent cause
of tropical diseases worldwide. Currently, no drugs are available for preventing or treating …