Molecular mechanisms of transgenerational epigenetic inheritance

MH Fitz-James, G Cavalli - Nature Reviews Genetics, 2022 - nature.com
Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …

Epigenetic inheritance of polycystic ovary syndrome—challenges and opportunities for treatment

E Stener-Victorin, Q Deng - Nature Reviews Endocrinology, 2021 - nature.com
Polycystic ovary syndrome (PCOS) is the main cause of female infertility worldwide and is
associated with a substantially increased lifetime risk of comorbidities, including type 2 …

DNA methylation-free Arabidopsis reveals crucial roles of DNA methylation in regulating gene expression and development

L He, H Huang, M Bradai, C Zhao, Y You, J Ma… - Nature …, 2022 - nature.com
A contribution of DNA methylation to defense against invading nucleic acids and
maintenance of genome integrity is uncontested; however, our understanding of the extent …

Functions and mechanisms of epigenetic inheritance in animals

K Skvortsova, N Iovino, O Bogdanović - Nature reviews Molecular cell …, 2018 - nature.com
The idea that epigenetic determinants such as DNA methylation, histone modifications or
RNA can be passed to the next generation through meiotic products (gametes) is long …

Environmentally induced epigenetic transgenerational inheritance of disease

EE Nilsson, I Sadler-Riggleman… - Environmental …, 2018 - academic.oup.com
Ancestral environmental exposures such as toxicants, abnormal nutrition or stress can
promote the epigenetic transgenerational inheritance of disease and phenotypic variation …

Transgenerational epigenetic inheritance

A Bošković, OJ Rando - Annual review of genetics, 2018 - annualreviews.org
Inheritance of genomic DNA underlies the vast majority of biological inheritance, yet it has
been clear for decades that additional epigenetic information can be passed on to future …

Deep inside the epigenetic memories of stressed plants

P Gallusci, DR Agius, PN Moschou, J Dobránszki… - Trends in Plant …, 2023 - cell.com
Recent evidence sheds light on the peculiar type of plant intelligence. Plants have
developed complex molecular networks that allow them to remember, choose, and make …

Crop improvement from phenotyping roots: highlights reveal expanding opportunities

SR Tracy, KA Nagel, JA Postma, H Fassbender… - Trends in plant …, 2020 - cell.com
Root systems determine the water and nutrients for photosynthesis and harvested products,
underpinning agricultural productivity. We highlight 11 programs that integrated root traits …

Nurse cell–derived small RNAs define paternal epigenetic inheritance in Arabidopsis

J Long, J Walker, W She, B Aldridge, H Gao, S Deans… - Science, 2021 - science.org
INTRODUCTION Epigenetic modifications to chromatin, such as the methylation of DNA
cytosines, carry regulatory information across the generations in plants and animals …

Bridging the explanatory gaps: What can we learn from a biological agency perspective?

SE Sultan, AP Moczek, D Walsh - BioEssays, 2022 - Wiley Online Library
We begin this article by delineating the explanatory gaps left by prevailing gene‐focused
approaches in our understanding of phenotype determination, inheritance, and the origin of …