[HTML][HTML] A localizing nanocarrier formulation enables multi-target immune responses to multivalent replicating RNA with limited systemic inflammation
T Kimura, JM Leal, A Simpson, NL Warner, BJ Berube… - Molecular Therapy, 2023 - cell.com
RNA vaccines possess significant clinical promise in counteracting human diseases caused
by infectious or cancerous threats. Self-amplifying replicon RNA (repRNA) has been thought …
by infectious or cancerous threats. Self-amplifying replicon RNA (repRNA) has been thought …
Generating prophylactic immunity against arboviruses in vertebrates and invertebrates
Abstract The World Health Organization recently declared a global initiative to control
arboviral diseases. These are mainly caused by pathogenic flaviviruses (such as dengue …
arboviral diseases. These are mainly caused by pathogenic flaviviruses (such as dengue …
[HTML][HTML] Self-Amplifying RNA: A Second Revolution of mRNA Vaccines against COVID-19
N Silva-Pilipich, U Beloki, L Salaberry, C Smerdou - Vaccines, 2024 - mdpi.com
SARS-CoV-2 virus, the causative agent of COVID-19, has produced the largest pandemic in
the 21st century, becoming a very serious health problem worldwide. To prevent COVID-19 …
the 21st century, becoming a very serious health problem worldwide. To prevent COVID-19 …
Alphavirus-based replicons demonstrate different interactions with host cells and can be optimized to increase protein expression
Alphaviruses have been used as vectors for the expression of heterologous genetic
information for a few decades. Their genomes contain two open reading frames. One of …
information for a few decades. Their genomes contain two open reading frames. One of …
[HTML][HTML] A replicating RNA vaccine confers protection in a rhesus macaque model of Crimean-Congo hemorrhagic fever
DW Hawman, SS Leventhal, K Meade-White… - npj Vaccines, 2024 - nature.com
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne febrile illness with a wide
geographic distribution. In recent years the geographic range of Crimean-Congo …
geographic distribution. In recent years the geographic range of Crimean-Congo …
[PDF][PDF] A polyvalent RNA vaccine reduces the immune imprinting phenotype in mice and induces neutralizing antibodies against omicron SARS-CoV-2
VPC Rocha, BAS Machado, BC Barreto, HC Quadros… - Heliyon, 2024 - cell.com
Immune imprinting is now evident in COVID-19 vaccinated people. This phenomenon may
impair the development of effective neutralizing antibodies against variants of concern …
impair the development of effective neutralizing antibodies against variants of concern …
Перемога мРНК-вакцин над пандемією коронавірусу SARS-CoV-2, який викликає захворювання COVID-19, або як синтетична мРНК прослизнула повз …
СВ Комісаренко, СІ Романюк - Вісник НАН України, 2023 - visnyk-nanu.org.ua
Анотація Нобелівську премію з фізіології або медицини у 2023 р. присуджено двом
вченим: угорсько-американському біохіміку Каталін Каріко (Katalin Karikó) та …
вченим: угорсько-американському біохіміку Каталін Каріко (Katalin Karikó) та …