Promising dawn in tumor microenvironment therapy: engineering oral bacteria

Z Wang, W Sun, R Hua, Y Wang, Y Li… - International Journal of …, 2024 - nature.com
Despite decades of research, cancer continues to be a major global health concern. The
human mouth appears to be a multiplicity of local environments communicating with other …

Biomembrane nanostructures: Multifunctional platform to enhance tumor chemoimmunotherapy via effective drug delivery

X Jiang, L Wu, M Zhang, T Zhang, C Chen, Y Wu… - Journal of Controlled …, 2023 - Elsevier
Chemotherapeutic drugs have been found to activate the immune response against tumors
by inducing immunogenic cell death, in addition to their direct cytotoxic effects toward …

[HTML][HTML] Engineered bacterial outer membrane vesicles: a versatile bacteria-based weapon against gastrointestinal tumors

K Zheng, Y Feng, L Li, F Kong, J Gao, X Kong - Theranostics, 2024 - ncbi.nlm.nih.gov
Outer membrane vesicles (OMVs) are nanoscale lipid bilayer structures released by gram-
negative bacteria. They share membrane composition and properties with their originating …

[HTML][HTML] Glucarpidase (carboxypeptidase G2): Biotechnological production, clinical application as a methotrexate antidote, and placement in targeted cancer therapy

F Moradbeygi, Y Ghasemi, AR Farmani… - Biomedicine & …, 2023 - Elsevier
Patients receiving high-dose methotrexate (HDMTX) for malignancies are exposed to
diverse complications, including nephrotoxicity, hepatotoxicity, mucositis, myelotoxicity …

Current advances in modulating tumor hypoxia for enhanced therapeutic efficacy

Z Liu, X Liu, W Zhang, R Gao, H Wei, CY Yu - Acta Biomaterialia, 2024 - Elsevier
Hypoxia is a common feature of most solid tumors, which promotes the proliferation,
invasion, metastasis, and therapeutic resistance of tumors. Researchers have been …

Engineered Microorganisms for Advancing Tumor Therapy

J Jia, X Wang, X Lin, Y Zhao - Advanced Materials, 2024 - Wiley Online Library
Engineered microorganisms have attracted significant interest as a unique therapeutic
platform in tumor treatment. Compared with conventional cancer treatment strategies …

Listeria-based vaccination against the pericyte antigen RGS5 elicits anti-vascular effects and colon cancer protection

TS Anderson, AL McCormick, EA Daugherity… - …, 2023 - Taylor & Francis
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality despite efforts
to improve standard interventions. As CRC patients can benefit from immunotherapeutic …

Deprivation of methionine inhibits osteosarcoma growth and metastasis via C1orf112-mediated regulation of mitochondrial functions

X Zhang, Z Zhao, X Wang, S Zhang, Z Zhao… - Cell Death & …, 2024 - nature.com
Osteosarcoma is a malignant bone tumor that primarily inflicts the youth. It often
metastasizes to the lungs after chemotherapy failure, which eventually shortens patients' …

Coated Bacteria: Advanced Living Materials for Microbial Therapy

Z Cao, J Liu - Accounts of Materials Research, 2024 - ACS Publications
Conspectus Living materials represent an emerging and innovative concept at the forefronts
of materials science due to the distinctive living characteristics. Living organisms, such as …

Bacteria-based drug delivery for treating non-oncological diseases

Z Cao, Y Pang, J Pu, J Liu - Journal of Controlled Release, 2024 - Elsevier
Bacteria inhabit all over the human body, especially the skin, gastrointestinal tract,
respiratory tract, urogenital tract, as well as specific lesion sites, such as wound and tumor …