Background We analysed incidence, predictors, histological features and specific treatment
options of anti-tumour necrosis factor α (TNF-α) antibody-induced psoriasiform skin lesions …

Alterations in barrier function are associated with a number of skin diseases, including
xerosis, atopic dermatitis, and psoriasis. Urea, a component of the natural moisturizing factor …

Genome-wide association studies (GWAS) have defined over 150 genomic regions
unequivocally containing variation predisposing to immune-mediated disease. Inferring …

Atopic dermatitis and psoriasis are 2 of the most common inflammatory skin diseases. They
are similar in that they are complex inherited diseases involving genes that encode immune …

The human major histocompatibility complex (MHC) region has been shown to be
associated with numerous diseases. However, it remains a challenge to pinpoint the causal …

Psoriasis is a complex disease with an expanding definition of its pathological features. We
sought to expand/refine the psoriasis transcriptome using 85 paired lesional and non …

We extended our previous genome-wide association study for psoriasis with a multistage
replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from …

Psoriasis is a chronic autoimmune disease with complex genetic architecture. Previous
genome-wide association studies (GWAS) and a recent meta-analysis using Immunochip …

To date, most genome-wide association studies (GWAS) and studies of fine-scale
population structure have been conducted primarily on Europeans. Han Chinese, the largest …

Psoriasis is a common inflammatory skin disease with complex genetics and different
degrees of prevalence across ethnic populations. Here we present the largest trans-ethnic …