Molecular mechanisms and therapeutic target of NETosis in diseases

J Huang, W Hong, M Wan, L Zheng - MedComm, 2022 - Wiley Online Library
Evidence shows that neutrophils can protect the host against pathogens in multiple ways,
including the formation and release of neutrophil extracellular traps (NETs). NETs are web …

Coagulation and complement: Key innate defense participants in a seamless web

ELG Pryzdial, A Leatherdale, EM Conway - Frontiers in immunology, 2022 - frontiersin.org
In 1969, Dr. Oscar Ratnoff, a pioneer in delineating the mechanisms by which coagulation is
activated and complement is regulated, wrote,“In the study of biological processes, the …

Inhibition of neutrophil extracellular trap formation alleviates vascular dysfunction in type 1 diabetic mice

C Liu, S Yalavarthi, A Tambralli, L Zeng… - Science …, 2023 - science.org
While neutrophil extracellular traps (NETs) have previously been linked to some diabetes-
associated complications, such as dysfunctional wound healing, their potential role in …

The expanding role of extracellular traps in inflammation and autoimmunity: the new players in casting dark webs

SUS Huang, KM O'Sullivan - International Journal of Molecular Sciences, 2022 - mdpi.com
The first description of a new form of neutrophil cell death distinct from that of apoptosis or
necrosis was discovered in 2004 and coined neutrophil extracellular traps “(NETs)” or …

Role and therapeutic targeting strategies of neutrophil extracellular traps in inflammation

X Li, S Xiao, N Filipczak, SSK Yalamarty… - International Journal …, 2023 - Taylor & Francis
Neutrophil extracellular traps (NETs) are large DNA reticular structures secreted by
neutrophils and decorated with histones and antimicrobial proteins. As a key mechanism for …

NETosis: an emerging therapeutic target in renal diseases

M Juha, A Molnár, Z Jakus, N Ledó - Frontiers in Immunology, 2023 - frontiersin.org
Introduction Neutrophil extracellular traps (NETs) are web-like structures composed of
nuclear and granular components. The primary role of NETS is to prevent the dissemination …

Immunomodulation and immunopharmacology in heart failure

G Markousis-Mavrogenis, L Baumhove… - Nature Reviews …, 2024 - nature.com
The immune system is intimately involved in the pathophysiology of heart failure. However, it
is currently underused as a therapeutic target in the clinical setting. Moreover, the …

PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury

X Du, B Ren, C Li, Q Li, S Kan, X Wang, W Bai… - Nature …, 2024 - nature.com
Excessive host immune responses contribute to severe malaria with high mortality. Here, we
show that PRL2 in innate immune cells is highly related to experimental malaria disease …

Neutrophils in autoimmunity: when the hero becomes the villain

S Bissenova, D Ellis, C Mathieu… - Clinical and …, 2022 - academic.oup.com
Neutrophils were long considered to be a short-lived homogenous cell population, limited to
their role as first responders in anti-bacterial and-fungal immunity. While it is true that …

Neutrophil extracellular traps in asthma: friends or foes?

R Poto, M Shamji, G Marone, SR Durham… - Cells, 2022 - mdpi.com
Asthma is a chronic inflammatory disease characterized by variable airflow limitation and
airway hyperresponsiveness. A plethora of immune and structural cells are involved in …