The contribution of X-linked coding variation to severe developmental disorders

HC Martin, EJ Gardner, KE Samocha, J Kaplanis… - Nature …, 2021 - nature.com
Over 130 X-linked genes have been robustly associated with developmental disorders, and
X-linked causes have been hypothesised to underlie the higher developmental disorder …

Shared genetic architectures of educational attainment in East Asian and European populations

TT Chen, J Kim, M Lam, YF Chuang, YL Chiu… - Nature Human …, 2024 - nature.com
Educational attainment (EduYears), a heritable trait often used as a proxy for cognitive
ability, is associated with various health and social outcomes. Previous genome-wide …

The human periconceptional maternal-embryonic space in health and disease

I Moreno, A Capalbo, A Mas… - Physiological …, 2023 - journals.physiology.org
Pregnancy is established during the periconceptional period as a continuum beginning with
blastocyst attachment to the endometrial epithelial surface followed by embryo invasion and …

Beyond safety: mapping the ethical debate on heritable genome editing interventions

M Almeida, R Ranisch - Humanities and Social Sciences …, 2022 - nature.com
Genetic engineering has provided humans the ability to transform organisms by direct
manipulation of genomes within a broad range of applications including agriculture (eg, GM …

[图书][B] Control: the dark history and troubling present of eugenics

A Rutherford - 2022 - books.google.com
How did an obscure academic idea pave the way to the Holocaust within just fifty years?
Control is a book about eugenics, what geneticist Adam Rutherford calls “a defining idea of …

Using DNA to predict intelligence

S von Stumm, R Plomin - Intelligence, 2021 - Elsevier
The DNA revolution made it possible to use DNA to predict intelligence. We argue that this
advance will transform intelligence research and society. Our paper has three objectives …

SALAI-Net: species-agnostic local ancestry inference network

B Oriol Sabat, D Mas Montserrat, X Giro-i-Nieto… - …, 2022 - academic.oup.com
Motivation Local ancestry inference (LAI) is the high resolution prediction of ancestry labels
along a DNA sequence. LAI is important in the study of human history and migrations, and it …

Patient interest in and clinician reservations on polygenic embryo screening: a qualitative study of stakeholder perspectives

D Barlevy, I Cenolli, T Campbell, R Furrer… - Journal of Assisted …, 2024 - Springer
Purpose We explored and compared perspectives of reproductive endocrinology and
infertility specialists (REIs) and in vitro fertilization (IVF) patients regarding polygenic embryo …

Public attitudes, interests, and concerns regarding polygenic embryo screening

RA Furrer, D Barlevy, S Pereira, S Carmi… - JAMA Network …, 2024 - jamanetwork.com
Importance Polygenic embryo screening (PES) is a novel technology that estimates the
likelihood of developing future conditions (eg, diabetes or depression) and traits (eg, height …

Polygenic scores in the direct-to-consumer setting: challenges and opportunities for a new era in consumer genetic testing

JK Park, CY Lu - Journal of Personalized Medicine, 2023 - mdpi.com
Direct-to-consumer (DTC) genetic tests have generated considerable scholarly attention and
public intrigue. Although the current consumer genetic testing regime relies on the reporting …