Background Machine learning (ML) models are beginning to proliferate in psychiatry,
however machine learning models in psychiatric genetics have not always accounted for …

Polygenic screening is a new form of embryo testing that assesses the probability that an
embryo will later develop a wide range of health conditions. This technology purports to help …

For 3 decades, couples at increased risk for a genetic disorder have been offered
preimplantation genetic testing (PGT). Simultaneously, PGT for aneuploidy (PGT‐A) to …

Human germline gene editing constitutes an extremely promising technology; at the same
time, however, it raises remarkable ethical, legal, and social issues. Although many of these …

Almost 150 y ago, Galton (1) pitted “nature” against “nurture.” In asking whether our
biological or environmental inheritance is more important in shaping our traits, Galton …

Research question What are the perspectives of preimplantation genetic testing patients in
Belgium on the ethics of preimplantation genetic testing for polygenic risk scoring (PGT-P) …

Biological systems are characterized by the ubiquitous roles of weak, that is, non-covalent
molecular interactions, small, often very small, numbers of specific molecules per cell, and …

We would like to thank the authors for their letter addressing our recent policy paper on PGT-
P, as this provides us with an additional opportunity to clarify our position. Tellier et al …

If polygenic risk scores for traits are to be provided to parents before—as opposed to after—
a child is born, these scores will provide the very first units of information upon which parents …

We use UK Biobank and a unique IVF family dataset (including genotyped embryos) to
investigate sibling variation in both phenotype and genotype. We compare phenotype …