A systematic review of the global intervention for SARS-CoV-2 combating: from drugs repurposing to molnupiravir approval

NA Ashour, A Abo Elmaaty, AA Sarhan… - Drug design …, 2023 - Taylor & Francis
The rising outbreak of SARS-CoV-2 continues to unfold all over the world. The development
of novel effective antiviral drugs to fight against SARS-CoV-2 is a time cost. As a result, some …

Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2

K Gao, R Wang, J Chen, L Cheng, J Frishcosy… - Chemical …, 2022 - ACS Publications
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …

[HTML][HTML] Precision therapeutic targets for COVID-19

ZA Krumm, GM Lloyd, CP Francis, LH Nasif… - Virology journal, 2021 - Springer
Beginning in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
emerged as a novel pathogen that causes coronavirus disease 2019 (COVID-19). SARS …

[HTML][HTML] A review on measures to rejuvenate immune system: Natural mode of protection against coronavirus infection

MA Islam, MA Haque, MA Rahman, F Hossen… - Frontiers in …, 2022 - frontiersin.org
SARS-CoV-2, a novel Corona virus strain, was first detected in Wuhan, China, in December
2019. As of December 16, 2021, almost 4,822,472 people had died and over 236,132,082 …

[HTML][HTML] A narrative review: The pharmaceutical evolution of phenolic syringaldehyde

J Wu, YS Fu, K Lin, X Huang, Y Chen, D Lai… - Biomedicine & …, 2022 - Elsevier
To better understand the pharmacological characters of syringaldehyde (SA), which is a key-
odorant compound of whisky and brandy, this review article is the first to compile the …

Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi

SH Kirsch, FPJ Haeckl, R Müller - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 2016 to 2022 RNA polymerase (RNAP) is the central enzyme in bacterial gene
expression representing an attractive and validated target for antibiotics. Two well-known …

Repurposing of FDA‐approved drugs against active site and potential allosteric drug‐binding sites of COVID‐19 main protease

M Yuce, E Cicek, T Inan, AB Dag… - Proteins: Structure …, 2021 - Wiley Online Library
The novel coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) still has serious negative effects on health, social …

[HTML][HTML] Rapamycin: drug repurposing in SARS-CoV-2 infection

J Patocka, K Kuca, P Oleksak, E Nepovimova, M Valis… - Pharmaceuticals, 2021 - mdpi.com
Since December 2019, SARS-CoV-2 (COVID-19) has been a worldwide pandemic with
enormous consequences for human health and the world economy. Remdesivir is the only …

[HTML][HTML] Molecular dynamics and in silico mutagenesis on the reversible inhibitor-bound SARS-CoV-2 main protease complexes reveal the role of lateral pocket in …

YL Weng, SR Naik, N Dingelstad, MR Lugo… - Scientific Reports, 2021 - nature.com
The 2019 novel coronavirus pandemic caused by SARS-CoV-2 remains a serious health
threat to humans and there is an urgent need to develop therapeutics against this deadly …

Molecular mechanisms of the novel coronavirus SARS-CoV-2 and potential anti-COVID19 pharmacological targets since the outbreak of the pandemic

D Vlachakis, E Papakonstantinou, T Mitsis… - Food and Chemical …, 2020 - Elsevier
The novel coronavirus SARS-CoV-2 has emerged as a severe threat against public health
and global economies. COVID-19, the disease caused by this virus, is highly contagious and …