Traditional pathogen detection methods in public health infectious disease surveillance rely
upon the identification of agents that are already known to be associated with a particular …

Highlights•Pathogen discovery is critically important to infectious diseases and public
health.•Nearly all new outbreaks are caused by the emergence of novel viruses.•Genomic …

Our understanding of the diversity and evolution of vertebrate RNA viruses is largely limited
to those found in mammalian and avian hosts and associated with overt disease. Here …

In 2018, the family Arenaviridae was expanded by inclusion of 1 new genus and 5 novel
species. At the same time, the recently established order Bunyavirales was expanded by 3 …

Low-cost DNA sequencing technologies have expanded the role for direct nucleic acid
sequencing in the analysis of genomes, transcriptomes, and the metagenomes of whole …

Until recently, members of the monogeneric family Arenaviridae (arenaviruses) have been
known to infect only muroid rodents and, in one case, possibly phyllostomid bats. The …

Emerging virus diseases are a major threat to human and veterinary public health. With new
examples occurring approximately one each year, the majority are viruses originating from …

It is hard to overemphasize the role that metagenomics has had on our recent understanding
of RNA virus diversity. Metagenomics in the 21st century has brought with it an explosion in …

Brilacidin (PMX30063) has shown potent bactericidal activity against drug-resistant and-
susceptible strains of multiple Gram-negative and Gram-positive pathogens. In this study, we …

Rapid, sensitive, and specific virus detection is an important component of clinical
diagnostics. Massively parallel sequencing enables new diagnostic opportunities that …