Introduction: Magnetic resonance imaging (MRI) enables direct measurements of muscle
volume and quality, allowing for an in-depth understanding of their associations with …

Background and aims Individuals with a higher abdominal adipose tissue accumulation are
at higher risk of developing cardiometabolic diseases. For a given body mass index (BMI) …

Background Epidemiologic studies have established obesity as a risk factor for multiple
sclerosis (MS). These studies relied on body-mass index (BMI) and body size silhouettes as …

Along with rich health-related metadata, medical images have been acquired for over
40,000 male and female UK Biobank participants, aged 44–82, since 2014. Phenotypes …

Genetic susceptibility to metabolic associated fatty liver disease (MAFLD) is complex and
poorly characterized. Accurate characterization of the genetic background of hepatic fat …

UK Biobank (UKB) has recruited more than 500 000 volunteers from the United Kingdom,
collecting health-related information on genetics, lifestyle, blood biochemistry, and more …

We aimed to unravel the mechanisms connecting adiposity to type 2 diabetes. We used MR-
Clust to cluster independent genetic variants associated with body fat percentage (388 …

Background Genetic factors influence the risk of fatty liver disease (FLD) in adults. The aim
of this study was to test if, and when, genetic risk factors known to affect FLD in adults begin …

Background The accumulation of visceral and ectopic fat comprise a major cause of
cardiometabolic diseases. However, novel drug targets for reducing unnecessary visceral …

Background Osteoporosis (OP) is a systemic skeletal disease characterized by
compromised bone strength leading to an increased risk of fracture. There is an ongoing …