Neurodevelopmental impairment remains a significant morbidity in former very low birth
weight premature infants. There is increasing evidence the microbiome affects …

Phenotyping of the CYP450 enzyme activities contributes to personalized medicine, but the
past phenotyping approaches have followed a piecemeal strategy measuring single enzyme …

Statins are widely prescribed medicines and are also available in fixed dose combinations
with other drugs to treat several chronic ailments. Given the safety issues associated with …

Recent advances in high-throughput gene sequencing and other omics biotechnologies
have served as a springboard for the field of pharmacogenomics. Pharmacogenomics is …

Knowledge of the ontogeny of Phase I and Phase II metabolizing enzymes may be used to
inform children's vulnerability based upon likely differences in internal dose from xenobiotic …

Purpose Vercirnon is a CCR9 chemokine receptor antagonist being developed for the
treatment of Crohn's disease. As a variety of concomitant medications are often required for …

Background: Limited sampling strategy (LSS) is a validated method to estimate
pharmacokinetic (PK) parameters from a reduced number of samples. Omeprazole is used …

Pharmacogenomics is a rapidly expanding field that will have a significant impact on patient
care and the role of healthcare professionals in providing personalized care. The clinical …