Biological and functional multimorbidity—from mechanisms to management
Globally, the number of people with multiple co-occurring diseases will increase
substantially over the coming decades, with important consequences for patients, carers …
substantially over the coming decades, with important consequences for patients, carers …
Advances and utility of the human plasma proteome
The study of proteins circulating in blood offers tremendous opportunities to diagnose,
stratify, or possibly prevent diseases. With recent technological advances and the urgent …
stratify, or possibly prevent diseases. With recent technological advances and the urgent …
[HTML][HTML] Plasma proteomic associations with genetics and health in the UK Biobank
Abstract The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium
characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we …
characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we …
[HTML][HTML] Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets
JH Zhao, D Stacey, N Eriksson… - Nature …, 2023 - nature.com
Circulating proteins have important functions in inflammation and a broad range of diseases.
To identify genetic influences on inflammation-related proteins, we conducted a genome …
To identify genetic influences on inflammation-related proteins, we conducted a genome …
Large-scale integration of the plasma proteome with genetics and disease
E Ferkingstad, P Sulem, BA Atlason… - Nature …, 2021 - nature.com
The plasma proteome can help bridge the gap between the genome and diseases. Here we
describe genome-wide association studies (GWASs) of plasma protein levels measured with …
describe genome-wide association studies (GWASs) of plasma protein levels measured with …
Mapping the proteo-genomic convergence of human diseases
INTRODUCTION Proteins are essential functional units of the human body and represent
the largest class of drug targets. RATIONALE Broad-capture proteomics has the potential to …
the largest class of drug targets. RATIONALE Broad-capture proteomics has the potential to …
[HTML][HTML] Large-scale plasma proteomics comparisons through genetics and disease associations
High-throughput proteomics platforms measuring thousands of proteins in plasma combined
with genomic and phenotypic information have the power to bridge the gap between the …
with genomic and phenotypic information have the power to bridge the gap between the …
Proteomic profiling platforms head to head: leveraging genetics and clinical traits to compare aptamer-and antibody-based methods
High-throughput proteomic profiling using antibody or aptamer-based affinity reagents is
used increasingly in human studies. However, direct analyses to address the relative …
used increasingly in human studies. However, direct analyses to address the relative …
[HTML][HTML] Synergistic insights into human health from aptamer-and antibody-based proteomic profiling
M Pietzner, E Wheeler, J Carrasco-Zanini… - Nature …, 2021 - nature.com
Affinity-based proteomics has enabled scalable quantification of thousands of protein targets
in blood enhancing biomarker discovery, understanding of disease mechanisms, and …
in blood enhancing biomarker discovery, understanding of disease mechanisms, and …
[HTML][HTML] Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn's disease: a multi-omics Mendelian randomization study
S Xu, X Li, S Zhang, C Qi, Z Zhang, R Ma, L Xiang… - BMC medicine, 2023 - Springer
Background Oxidative stress (OS) is a key pathophysiological mechanism in Crohn's
disease (CD). OS-related genes can be affected by environmental factors, intestinal …
disease (CD). OS-related genes can be affected by environmental factors, intestinal …