ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

The two main pathological hallmarks of Parkinson's disease are loss of dopamine neurons
in the substantia nigra pars compacta and proteinaceous amyloid fibrils composed mostly of …

Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100
years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence …

Neurodegenerative disease (NDD), including Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, are characterized by the progressive loss of neurons which …

Spreading of aggregate pathology across brain regions acts as a driver of disease
progression in Tau-related neurodegeneration, including Alzheimer's disease (AD) and …

Prion‐like transcellular spreading of tau in Alzheimer's Disease (AD) is mediated by tau
binding to cell surface heparan sulfate (HS). However, the structural determinants for tau …

Alzheimer's Disease (AD) therapeutics based on the amyloid hypothesis have repeatedly
failed in clinical trials. Together with numerous reports that amyloid is present in brains from …

The process of uncontrolled internal scarring, called fibrosis, is now emerging as a
pathological feature shared by both peripheral and central nervous system diseases. In the …

Glycosaminoglycans (GAGs) are long, linear polysaccharides that are ubiquitously
expressed on the cell surface and in the extracellular matrix of all animal cells. These …

Tauopathies are a heterogenous family of progressive neurodegenerative diseases defined
by the appearance of proteinaceous lesions within the brain composed of abnormally folded …