Neurotoxicity of ochratoxin A: Molecular mechanisms and neurotherapeutic strategies

BA Obafemi, IA Adedara, JBT Rocha - Toxicology, 2023 - Elsevier
Data from epidemiological and experimental studies evidenced that some chemical
contaminants in food elicit their harmful effects by targeting the central nervous system …

Endothelial type I interferon response and brain diseases: identifying STING as a therapeutic target

N Duarte, AM Shafi, C Penha-Gonçalves… - Frontiers in Cell and …, 2023 - frontiersin.org
The endothelium layer lining the inner surface of blood vessels serves relevant
physiological functions in all body systems, including the exchanges between blood and …

Exposure to different surface-modified polystyrene nanoparticles caused anxiety, depression, and social deficit in mice via damaging mitochondria in neurons

Y Ma, D Xu, Z Wan, Z Wei, Z Chen, Y Wang… - Science of The Total …, 2024 - Elsevier
Nanoplastics (NPs) are unavoidable hazardous materials that result from the human
production and use of plastics. While there is evidence that NPs can bioaccumulate in the …

Engineered exosomes derived from stem cells: a new brain-targeted strategy

W Ahmed, S Huang, L Chen - Expert Opinion on Drug Delivery, 2024 - Taylor & Francis
Introduction Using engineered exosomes produced from stem cells is an experimental
therapeutic approach for treating brain diseases. According to reports, preclinical research …

Neuroprotective compounds from marine invertebrates

B Rivai, AK Umar - Beni-Suef University Journal of Basic and Applied …, 2023 - Springer
Background Neuroinflammation is a key pathological feature of a wide variety of
neurological disorders, including Parkinson's, multiple sclerosis, Alzheimer's, and …

SARS-CoV-2 causes dysfunction in human iPSC-derived brain microvascular endothelial cells potentially by modulating the Wnt signaling pathway

S Yamada, T Hashita, S Yanagida, H Sato… - Fluids and Barriers of …, 2024 - Springer
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
coronavirus disease 2019 (COVID-19), which is associated with various neurological …

Insights into epileptogenesis from post-traumatic epilepsy

M Pease, K Gupta, SL Moshé, DJ Correa… - Nature Reviews …, 2024 - nature.com
Post-traumatic epilepsy (PTE) accounts for 5% of all epilepsies. The incidence of PTE after
traumatic brain injury (TBI) depends on the severity of injury, approaching one in three in …

Mechanistic Intimate Insights into the Role of Hydrogen Sulfide in Alzheimer's Disease: A Recent Systematic Review

C Munteanu, DA Iordan, M Hoteteu, C Popescu… - International Journal of …, 2023 - mdpi.com
In the rapidly evolving field of Alzheimer's Disease (AD) research, the intricate role of
Hydrogen Sulfide (H2S) has garnered critical attention for its diverse involvement in both …

SARS‐CoV‐2 induces blood‐brain barrier and choroid plexus barrier impairments and vascular inflammation in mice

H Qiao, X Deng, L Qiu, Y Qu, Y Chiu… - Journal of medical …, 2024 - Wiley Online Library
The coronavirus disease of 2019 (COVID‐19) pandemic has led to more than 700 million
confirmed cases and nearly 7 million deaths. Although severe acute respiratory syndrome …

Toxicologic neuropathology of novel biotherapeutics

DS Bangari, LG Lanigan, SD Cramer, JL Grieves… - 2023 - journals.sagepub.com
Biotherapeutic modalities such as cell therapies, gene therapies, nucleic acids, and proteins
are increasingly investigated as disease-modifying treatments for severe and life …