An imbalance in oxygen supply and demand......................................................................... 337
Experimental evidence for possible mechanisms of benefit from beta blockade in acute MI …

Background—Age is an important determinant of outcomes for patients with acute coronary
syndromes. However, community practice reveals a disproportionately lower use of …

The content of these European Society of Cardiology (ESC) Guidelines has been published
for personal and educational use only. No commercial use is authorized. No part of the ESC …

A key principle for interpretation of subgroup results is that quantitative interactions
(differences in degree) are much more likely than qualitative interactions (differences in …

Background Despite previous randomised trials of early β-blocker therapy in the emergency
treatment of myocardial infarction (MI), uncertainty has persisted about the value of adding it …

OBJECTIVE--To establish whether treatment with diuretic or beta blocker in hypertensive
older adults reduces risk of stroke, coronary heart disease, and death. DESIGN …

The clinical presentations of ischaemic heart disease include stable angina pectoris, silent
ischaemia, unstable angina, myocardial infarction, heart failure, and sudden death. For …

Background: The impact of intravenous (IV) beta-blockers before primary percutaneous
coronary intervention (PPCI) on infarct size and clinical outcomes is not well established …

Background Patients who have acute myocardial infarction remain at major risk of
cardiovascular events. We aimed to assess the effects of either human atrial natriuretic …

Now updated with new data and examples throughout, Clinical Epidemiology: Principles,
Methods, and Applications for Clinical Research, Second Edition is a comprehensive …