It's in the blood: a review of the hematological system in SARS-CoV-2-associated COVID-19

JV Harte, C Coleman-Vaughan… - Critical Reviews in …, 2023 - Taylor & Francis
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led
to an unprecedented global healthcare crisis. While SARS-CoV-2-associated COVID-19 …

Deciphering the role of monocyte and monocyte distribution width (MDW) in COVID-19: an updated systematic review and meta-analysis

D Ligi, B Lo Sasso, BM Henry, M Ciaccio… - Clinical Chemistry and …, 2023 - degruyter.com
The SARS-CoV-2 infection is characterized by both systemic and organ hyper-
thromboinflammation, with a clinical course ranging from mild up-to critical systemic …

Circulating histones contribute to monocyte and MDW alterations as common mediators in classical and COVID-19 sepsis

D Ligi, B Lo Sasso, RV Giglio, R Maniscalco… - Critical Care, 2022 - Springer
Objective Histone proteins are physiologically involved in DNA packaging and gene
regulation but are extracellularly released by neutrophil/monocyte extracellular traps and …

Prognostic role of monocyte distribution width, CRP, procalcitonin and lactate as sepsis biomarkers in critically Ill COVID-19 patients

D Bajić, J Matijašević, L Andrijević, B Zarić… - Journal of Clinical …, 2023 - mdpi.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global
pandemic and one group of patients has developed a severe form of COVID-19 pneumonia …

A two-gene marker for the two-tiered innate immune response in COVID-19 patients

H Lei - PLoS One, 2023 - journals.plos.org
For coronavirus disease 2019 (COVID-19), a pandemic disease characterized by strong
immune dysregulation in severe patients, convenient and efficient monitoring of the host …

Monocyte distribution width alterations and cytokine storm are modulated by circulating histones

D Ligi, B Lo Sasso, C Della Franca… - Clinical Chemistry and …, 2023 - degruyter.com
Objectives Extracellular histone levels are associated with the severity of many human
pathologies, including sepsis and COVID-19. This study aimed to investigate the role of …

Increased monocyte distribution width in COVID‐19 and sepsis arises from a complex interplay of altered monocyte cellular size and subset frequency

M Cusinato, L Hadcocks, S Yona… - International Journal …, 2022 - Wiley Online Library
Introduction Monocyte distribution width (MDW), a parameter generated alongside full blood
counts (FBC) in new‐generation haematology analysers, has been proposed as a …

Monocyte Distribution Width (MDW) as a biomarker of sepsis: An evidenced-based laboratory medicine approach

AM Ciaccio, L Agnello, BL Sasso, RV Giglio… - Clinica Chimica …, 2023 - Elsevier
Abstract Monocyte Distribution Width (MDW) is a new generation cell blood count parameter
providing a measure of monocyte anisocytosis. In the last decades, it has emerged as a …

Distinct post-sepsis induced neurochemical alterations in two mouse strains

CA Browne, G Clarke, P Fitzgerald, J O'Sullivan… - Brain, behavior, and …, 2022 - Elsevier
Sepsis associated encephalopathy, occurs in 70% of severe septic cases, following which
survivors exhibit long-term cognitive impairment or global loss of cognitive function …

Monocyte distribution width as an early predictor of short-term outcome in adult patients with sepsis

Y Liu, R Wang, S Zhong, L Qian… - Clinical Chemistry and …, 2024 - degruyter.com
Objectives Monocyte distribution width (MDW) is a quantitative measurement of monocyte
anisocytosis and has been proposed as an efficient marker for early sepsis detection. This …