Remarkable recent advances have revolutionized the field of heart failure. Survival has
improved among individuals with heart failure and a reduced ejection fraction and for the …

The cardiovascular system requires iron to maintain its high energy demands and metabolic
activity. Iron plays a critical role in oxygen transport and storage, mitochondrial function, and …

Genetically modified xenografts are one of the most promising solutions to the discrepancy
between the numbers of available human organs for transplantation and potential recipients …

Background Left bundle branch pacing (LBBP) is the most rapidly growing conduction
system pacing technique that is capable of correcting intrinsic left bundle branch block …

BACKGROUND: Multivariable equations are recommended by primary prevention
guidelines to assess absolute risk of cardiovascular disease (CVD). However, current …

Abstract Angiotensin-converting enzyme 2 (ACE2) has proven beneficial in attenuating
diabetic cardiomyopathy (DCM) but has been found to be a substrate of a disintegrin and …

Abstract Background and Aims Whereas a beneficial effect of intravenous ferric
carboxymaltose (FCM) on symptoms and exercise capacity among patients with iron …

Diagnosing heart failure is often difficult due to the non‐specific nature of symptoms, which
can be caused by a range of medical conditions. Natriuretic peptides (NPs) have been …

Background: The prevalence of heart failure with mildly reduced or preserved ejection
fraction markedly increases with age, with older individuals disproportionately facing excess …

Background US guidelines recommend consideration of sacubitril/valsartan in chronic heart
failure (HF) and mildly reduced or preserved ejection fraction (EF). Whether initiation is safe …