JAK-STAT pathway inhibition and their implications in COVID-19 therapy

S Satarker, AA Tom, RA Shaji, A Alosious… - Postgraduate …, 2021 - Taylor & Francis
As the incidence of COVID-19 increases with time, more and more efforts are made to pave
a way out for the therapeutic strategies to deal with the disease progression. Inflammation …

The dynamic association between COVID-19 and chronic disorders: An updated insight into prevalence, mechanisms and therapeutic modalities

SK Alyammahi, SM Abdin, DW Alhamad… - Infection, Genetics and …, 2021 - Elsevier
The devastating pandemic of coronavirus disease 2019 (COVID-19) has caused thousands
of deaths and left millions of restless patients suffering from its complications. Increasing …

[HTML][HTML] SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

P Pan, M Shen, Z Yu, W Ge, K Chen, M Tian… - Nature …, 2021 - nature.com
Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with
severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 …

[HTML][HTML] Mast cell and eosinophil activation are associated with COVID-19 and TLR-mediated viral inflammation: implications for an anti-Siglec-8 antibody

S Gebremeskel, J Schanin, KM Coyle… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection represents a
global health crisis. Immune cell activation via pattern recognition receptors has been …

[HTML][HTML] Potential adverse effects of dexamethasone therapy on COVID-19 patients: review and recommendations

F Chen, L Hao, S Zhu, X Yang, W Shi, K Zheng… - Infectious diseases and …, 2021 - Springer
In the context of the coronavirus disease 2019 (COVID-19) pandemic, the global healthcare
community has raced to find effective therapeutic agents against severe acute respiratory …

[HTML][HTML] Cytokine storm syndrome in SARS-CoV-2 infections: a functional role of mast cells

B Hafezi, L Chan, JP Knapp, N Karimi, K Alizadeh… - Cells, 2021 - mdpi.com
Cytokine storm syndrome is a cascade of escalated immune responses disposing the
immune system to exhaustion, which might ultimately result in organ failure and fatal …

Inflammatory cytokine: IL-17A signaling pathway in patients present with COVID-19 and current treatment strategy

T Shibabaw - Journal of inflammation research, 2020 - Taylor & Francis
Abstract Coronavirus disease 2019 (COVID-19) is a globally communicable public health
disease caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV-2) …

Evaluation of the relationship between serum levels of zinc, vitamin B12, vitamin D, and clinical outcomes in patients with COVID‐19

H Shakeri, A Azimian… - Journal of medical …, 2022 - Wiley Online Library
Due to the known anti‐inflammatory and antiviral effects of zinc, 25 (OH) D, and vitamin B12,
in this study, we explored the association between serum levels of these micronutrients in …

[HTML][HTML] NLRP3 inflammasome activation and SARS-CoV-2-mediated hyperinflammation, cytokine storm and neurological syndromes

D Dutta, J Liu, H Xiong - International journal of physiology …, 2022 - ncbi.nlm.nih.gov
Despite the introduction of vaccines and drugs for SARS-CoV-2, the COVID-19 pandemic
continues to spread throughout the world. In severe COVID-19 patients, elevated levels of …

[HTML][HTML] Anti-inflammatory and antimicrobial volatile oils: Fennel and cumin inhibit neutrophilic inflammation via regulating calcium and MAPKs

M Korinek, H Handoussa, YH Tsai, YY Chen… - Frontiers in …, 2021 - frontiersin.org
Neutrophilic inflammatory diseases, such as chronic obstructive pulmonary disease (COPD),
acute respiratory distress syndrome (ARDS), or psoriasis, exert a huge burden on the global …