Background The evidence on selective serotonin reuptake inhibitors (SSRIs) for major
depressive disorder is unclear. Methods Our objective was to conduct a systematic review …

Background Evidence-based medicine (EBM) has always required integration of patient
values with 'best'clinical evidence. It is widely recognized that scientific practices and …

In the past decades, reductionism has dominated both research directions and funding
policies in clinical psychology and psychiatry. The intense search for the biological basis of …

The role of values in scientific research has become an important topic of discussion in both
scholarly and popular debates. Pundits across the political spectrum worry that research on …

Globally, the number of drug prescriptions is increasing causing more adverse drug events,
which is now a significant cause of mortality, morbidity, and disability that has reached …

Conclusions—Patients with mild depression or uncomplicated grief reaction usually have a
good prognosis and don't need drug treatment. Clinicians should focus on identifying people …

I've spent most of my professional life to evaluate the quality of clinical research, and I think it
is particularly poor in psychiatry. Industry-sponsored studies... are selectively published, are …

In response to the questioning of Health Policy and Management (HPAM) by colleagues on
the role of rank and file family physicians in the same journal, the author, a family physician …

Meta-analyses indicate that antidepressants are superior to placebos in statistical terms, but
the clinical relevance of the differences has not been established. Previous suggestions of …

Consistent with well-established biochemical properties of coronaviruses, sialylated glycan
attachments between SARS-CoV-2 spike protein (SP) and host cells are key to the virus's …