Immune ageing at single-cell resolution
Ageing leads to profound alterations in the immune system and increases susceptibility to
some chronic, infectious and autoimmune diseases. In recent years, widespread application …
some chronic, infectious and autoimmune diseases. In recent years, widespread application …
[PDF][PDF] Adaptive immunity to SARS-CoV-2 and COVID-19
The adaptive immune system is important for control of most viral infections. The three
fundamental components of the adaptive immune system are B cells (the source of …
fundamental components of the adaptive immune system are B cells (the source of …
Inflammation and aging: signaling pathways and intervention therapies
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
[PDF][PDF] Comprehensive profiling of an aging immune system reveals clonal GZMK+ CD8+ T cells as conserved hallmark of inflammaging
Systematic understanding of immune aging on a whole-body scale is currently lacking. We
characterized age-associated alterations in immune cells across multiple mouse organs …
characterized age-associated alterations in immune cells across multiple mouse organs …
Immunosenescence and its hallmarks: how to oppose aging strategically? A review of potential options for therapeutic intervention
A Aiello, F Farzaneh, G Candore, C Caruso… - Frontiers in …, 2019 - frontiersin.org
Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …
Immunosenescence and human vaccine immune responses
SN Crooke, IG Ovsyannikova, GA Poland… - Immunity & …, 2019 - Springer
The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …
“immunosenescence”—has been generally associated with an increased susceptibility to …
[HTML][HTML] Emerging concepts and technologies in vaccine development
Despite the success of vaccination to greatly mitigate or eliminate threat of diseases caused
by pathogens, there are still known diseases and emerging pathogens for which the …
by pathogens, there are still known diseases and emerging pathogens for which the …
Effects of sex and aging on the immune cell landscape as assessed by single-cell transcriptomic analysis
Z Huang, B Chen, X Liu, H Li, L Xie… - Proceedings of the …, 2021 - National Acad Sciences
Sex and aging influence the human immune system, resulting in disparate responses to
infection, autoimmunity, and cancer. However, the impact of sex and aging on the immune …
infection, autoimmunity, and cancer. However, the impact of sex and aging on the immune …
The twilight of immunity: emerging concepts in aging of the immune system
J Nikolich-Žugich - Nature immunology, 2018 - nature.com
Immunosenescence is a series of age-related changes that affect the immune system and,
with time, lead to increased vulnerability to infectious diseases. This Review addresses …
with time, lead to increased vulnerability to infectious diseases. This Review addresses …
[PDF][PDF] CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity
To better understand primary and recall T cell responses during coronavirus disease 2019
(COVID-19), it is important to examine unmanipulated severe acute respiratory syndrome …
(COVID-19), it is important to examine unmanipulated severe acute respiratory syndrome …