During severe inflammatory and infectious diseases, various mediators modulate the
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …

New components and functions of the renin‐angiotensin system (RAS) are still being
unravelled. The classical RAS as it looked in the middle 1970s consisted of circulating renin …

About 330 targets bind approved drugs, 270 encoded by the human genome and 60
belonging to pathogenic organisms. A large number of druggable targets have been …

Human aminopeptidase N (hAPN/hCD13) is a dimeric membrane protein and a member of
the M1 family of zinc metallopeptidases. Within the rennin-angiotensin system, its enzymatic …

Cardiovascular diseases (CVDs) are the main contributors to global morbidity and mortality.
Major pathogenic phenotypes of CVDs include the development of endothelial dysfunction …

In the human genome, the aminopeptidases ERAP1, ERAP2 and LNPEP lie contiguously on
chromosome 5. They share sequence homology, functions and associations with immune …

Abstract Angiotensin-(1–9)[Ang-(1–9)] is a peptide of the non-canonical renin-angiotensin
system (RAS) synthesized from angiotensin I by the monopeptidase angiotensin-converting …

For decades, angiotensin (Ang) II was considered as the end product and the only bioactive
peptide of the renin–angiotensin system (RAS). However, later studies revealed biological …

Rheological, haemostatic, endothelial and platelet abnormalities appear to play a role in the
thrombotic complications of hypertension. This prothrombotic/hypercoagulable state in …

Although initially considered relatively harmless pathogens, human coronaviruses (HCoVs)
are nowadays known to be associated with more severe clinical complications. Still, their …