Key substitutions in the spike protein of SARS-CoV-2 variants can predict resistance to monoclonal antibodies, but other substitutions can modify the effects

S Lusvarghi, W Wang, R Herrup… - Journal of …, 2022 - Am Soc Microbiol
Mutations in the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants can compromise the effectiveness of therapeutic antibodies. Most clinical …

A single amino acid at residue 188 of the hexon protein is responsible for the pathogenicity of the emerging novel virus fowl adenovirus 4

Y Zhang, A Liu, Y Wang, H Cui, Y Gao, X Qi… - Journal of …, 2021 - Am Soc Microbiol
Since 2015, severe hydropericardium-hepatitis syndrome (HHS) associated with a novel
fowl adenovirus 4 (FAdV-4) has emerged in China, representing a new challenge for the …

SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction

C Hirunpattarasilp, G James, J Kwanthongdee… - Brain, 2023 - academic.oup.com
Abstract The SARS-CoV-2 receptor, ACE2, is found on pericytes, contractile cells
enwrapping capillaries that regulate brain, heart and kidney blood flow. ACE2 converts …

[HTML][HTML] Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 variants via multiplex assay

E Lopez, ER Haycroft, A Adair, FL Mordant, MT O'Neill… - JCI insight, 2021 - ncbi.nlm.nih.gov
The SARS-CoV-2 receptor binding domain (RBD) is both the principal target of neutralizing
antibodies and one of the most rapidly evolving domains, which can result in the emergence …

Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles

E Touizer, A Alrubayyi, R Ford, N Hussain, PP Gerber… - Iscience, 2023 - cell.com
We assessed a cohort of people living with human immunodeficiency virus (PLWH)(n= 110)
and HIV negative controls (n= 64) after 1, 2 or 3 SARS-CoV-2 vaccine doses. At all …

Genetic drift in the genome of SARS COV‐2 and its global health concern

I Bano, M Sharif, S Alam - Journal of Medical Virology, 2022 - Wiley Online Library
The outbreak of the current coronavirus disease (COVID‐19) occurred in late 2019 and
quickly spread all over the world. The severe acute respiratory syndrome coronavirus‐2 …

Enhanced antibody responses in fully vaccinated individuals against pan-SARS-CoV-2 variants following Omicron breakthrough infection

HW Jeong, SM Kim, MK Jung, JY Noh, JS Yoo… - Cell Reports …, 2022 - cell.com
Omicron has become the globally dominant severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) variant, creating additional challenges due to its ability to evade …

Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape

R Marzi, J Bassi, C Silacci-Fregni, I Bartha, F Muoio… - Iscience, 2023 - cell.com
Memory B cells (MBCs) generate rapid antibody responses upon secondary encounter with
a pathogen. Here, we investigated the kinetics, avidity, and cross-reactivity of serum …

[HTML][HTML] Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B. 1.1. 7 variant

AK Reuschl, LG Thorne, L Zuliani-Alvarez… - BioRxiv, 2021 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths worldwide and …

A SARS‐CoV‐2 Neutralization Assay Using Single Molecule Arrays

T Gilboa, L Cohen, CA Cheng… - Angewandte Chemie …, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) manifests with high clinical variability and
warrants sensitive and specific assays to analyze immune responses in infected and …