A third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concern

M Brinkkemper, PJM Brouwer, P Maisonnasse… - npj Vaccines, 2021 - nature.com
The emergence of SARS-CoV-2 variants that are more resistant to antibody-mediated
neutralization pose a new hurdle in combating the COVID-19 pandemic. Although vaccines …

[PDF][PDF] Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape

R Marzi, J Bassi, C Silacci-Fregni, I Bartha, F Muoio… - Iscience, 2023 - cell.com
Memory B cells (MBCs) generate rapid antibody responses upon secondary encounter with
a pathogen. Here, we investigated the kinetics, avidity, and cross-reactivity of serum …

Production of neutralizing antibody fragment variants in the cytoplasm of E. coli for rapid screening: SARS-CoV-2 a case study

AA Tungekar, R Recacha, LW Ruddock - Scientific Reports, 2023 - nature.com
Global health challenges such as the coronavirus pandemic warrant the urgent need for a
system that allows efficient production of diagnostic and therapeutic interventions. Antibody …

[HTML][HTML] Impact of the B. 1.1. 7 variant on neutralizing monoclonal antibodies recognizing diverse epitopes on SARS-CoV-2 Spike

C Graham, J Seow, I Huettner, H Khan, N Kouphou… - bioRxiv, 2021 - ncbi.nlm.nih.gov
The interaction of the SARS-CoV-2 Spike receptor binding domain (RBD) with the ACE2
receptor on host cells is essential for viral entry. RBD is the dominant target for neutralizing …

Anti-fungal drug anidulafungin inhibits SARS-CoV-2 spike-induced syncytia formation by targeting ACE2-spike protein interaction

S Ahamad, H Ali, I Secco, M Giacca, D Gupta - Frontiers in Genetics, 2022 - frontiersin.org
Drug repositioning continues to be the most effective, practicable possibility to treat COVID-
19 patients. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus …

A brief overview of SARS-CoV-2 infection and its management strategies: a recent update

A Das, S Pathak, M Premkumar… - Molecular and Cellular …, 2023 - Springer
The COVID-19 pandemic has become a global health crisis, inflicting substantial morbidity
and mortality worldwide. A diverse range of symptoms, including fever, cough, dyspnea, and …

Structural insights into protection against a SARS-CoV-2 spike variant by T cell receptor diversity

D Wu, GA Efimov, AV Bogolyubova, BG Pierce… - Journal of Biological …, 2023 - ASBMB
T cells play a crucial role in combatting SARS-CoV-2 and forming long-term memory
responses to this coronavirus. The emergence of SARS-CoV-2 variants that can evade T cell …

Mutations in the receptor-binding domain of human SARS CoV-2 spike protein increases its affinity to bind human ACE-2 receptor

GKRS Naresh, L Guruprasad - Journal of Biomolecular Structure …, 2023 - Taylor & Francis
The severe acute respiratory syndrome virus-2 (SARS CoV-2) infection has resulted in the
current global pandemic. The binding of SARS CoV-2 spike protein receptor-binding domain …

COVID‐19 in gastroenterology: where are we now? Current evidence on the impact of COVID‐19 in gastroenterology

F Magro, A Nuzzo, C Abreu, D Libânio… - UEG …, 2021 - Wiley Online Library
Background The COVID‐19 pandemic has created unprecedented challenges in all fields of
society with social, economic, and health‐related consequences worldwide. In this context …

[HTML][HTML] Rapid assessment of binding affinity of SARS-COV-2 spike protein to the human angiotensin-converting enzyme 2 receptor and to neutralizing biomolecules …

D Buratto, A Saxena, Q Ji, G Yang, S Pantano… - Frontiers in …, 2021 - frontiersin.org
SARS-CoV-2 infects humans and causes Coronavirus disease 2019 (COVID-19). The S1
domain of the spike glycoprotein of SARS-CoV-2 binds to human angiotensin-converting …