Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants

Z Liu, H Wu, KA Egland, TC Gilliland… - Human Vaccines & …, 2022 - Taylor & Francis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with amino-acid
substitutions and deletions in spike protein (S) can reduce the effectiveness of monoclonal …

[HTML][HTML] The challenge of emerging SARS-CoV-2 mutants to vaccine development

R Li, J Liu, H Zhang - Journal of Genetics and Genomics, 2021 - ncbi.nlm.nih.gov
Since the outbreak of the pandemic, waves of epidemics caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants that harbor novel mutations have never …

Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences

JY Lee, PAC Wing, DS Gala, M Noerenberg, AI Järvelin… - Elife, 2022 - elifesciences.org
Despite an unprecedented global research effort on SARS-CoV-2, early replication events
remain poorly understood. Given the clinical importance of emergent viral variants with …

Recent development of microfluidics-based platforms for respiratory virus detection

J Shi, Y Zhang, M Yang - Biomicrofluidics, 2023 - pubs.aip.org
With the global outbreak of SARS-CoV-2, the inadequacies of current detection technology
for respiratory viruses have been recognized. Rapid, portable, accurate, and sensitive …

[PDF][PDF] Persistence of functional memory B cells recognizing SARS-CoV-2 variants despite loss of specific IgG

S Winklmeier, K Eisenhut, D Taskin, H Rübsamen… - Iscience, 2022 - cell.com
Although some COVID-19 patients maintain SARS-CoV-2-specific serum immunoglobulin G
(IgG) for more than 6 months postinfection, others eventually lose IgG levels. We assessed …

Tracking the pipeline: immunoinformatics and the COVID-19 vaccine design

S Rezaei, Y Sefidbakht… - Briefings in Bioinformatics, 2021 - academic.oup.com
With the onset of the COVID-19 pandemic, the amount of data on genomic and proteomic
sequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stored in …

SARS-CoV-2 variants: mutations and effective changes

G Park, BH Hwang - Biotechnology and Bioprocess Engineering, 2021 - Springer
One of the primary threats to the goal of controlling and eventually defeating SARS-CoV-2 is
that of mutation. Recognizing this, a great amount of effort and dedicated study is being …

Persistence of humoral response upon SARS‐CoV‐2 infection

A Knies, D Ladage, RJ Braun, J Kimpel… - Reviews in Medical …, 2022 - Wiley Online Library
SARS‐CoV‐2 continues to leave its toll on global health and the economy. Management of
the pandemic will rely heavily on the degree of adaptive immunity persistence following …

Are convalescent plasma stocks collected during former COVID‐19 waves still effective against current SARS‐CoV‐2 variants?

D Focosi, M Franchini, MJ Joyner… - Vox sanguinis, 2022 - Wiley Online Library
Abstract COVID‐19 convalescent plasma (CCP) was among the few frontline therapies used
to treat COVID‐19. After large randomized controlled trials (RCTs) relying on late use in …

Humoral and cellular responses to SARS‐CoV‐2 in patients with B‐cell haematological malignancies improve with successive vaccination

CL Pinder, D Jankovic, TA Fox… - British Journal of …, 2023 - Wiley Online Library
Patients with haematological malignancies are more likely to have poor responses to
vaccination. Here we provide detailed analysis of the humoral and cellular responses to …