1, 8-Naphthalimide, as one of the classical dyes and fluorophores, has been widely used in
analytical chemistry, materials chemistry, and biochemistry fields because of its excellent …

CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR-
associated) proteins are powerful gene-editing tools because of their ability to accurately …

The development of a sensing platform with high sensitivity and specificity, especially
programmability and universal applicability, for the detection of clinically relevant molecules …

To maintain the stability and integrity of cellular genomic DNA, DNA repair enzymes catalyze
the repair of DNA damage caused by exogenous and endogenous factors through various …

We reported a CRISPR/Cas-based dual amplified sensing strategy for rapid, sensitive and
selective detection of polynucleotide kinase/phosphatase (PNKP), a DNA damage repair …

Nanozymes are nanomaterials with intrinsic enzyme-like properties. Since the landmark
research report on nanozymes in 2007, numerous scientists focus on the topic of nanozyme …

Sensitive monitoring of intracellular uracil-DNA glycosylase (UDG) in living cells is essential
to understanding the DNA repair pathways and discovery of anticancer drugs. Herein, we …

Uracil DNA glycosylase (UDG) is one of the key initiators for the base excision repair
pathway. Since abnormal UDG expression is associated with various diseases, sensitive …

In addition to their roles as revolutionary genome engineering tools, CRISPR-Cas systems
are also highly promising candidates in the construction of biosensing systems and …

Considering the trans-cleavage capabilities, high-specificity and programmability, the
CRISPR-Cas system has been recognized as a valuable platform to develop the next …