Immune cells undergo rapid and extensive metabolic changes during inflammation. In
addition to contributing to energetic and biosynthetic demands, metabolites can also …

Stimulator of interferon genes (STING) is a crucial innate immune sensor responsible for
distinguishing pathogens and cytosolic DNA, mediating innate immune signaling pathways …

The presence of heterogeneity in responses to oncolytic virotherapy poses a barrier to
clinical effectiveness, as resistance to this treatment can occur through the inhibition of viral …

Despite medical advances, there remains an unmet need for better treatment of obesity.
Itaconate, a product of the decarboxylation of the tricarboxylic acid cycle intermediate cis …

Mitochondrial metabolites and their derivatives have been the focus of recent efforts to
develop new anti-inflammatory therapeutics. The widely used therapeutic agents dimethyl …

Despite the well-established functions of protein palmitoylation in fundamental cellular
processes, the roles of this reversible post-translational lipid modification in cardiomyocyte …

Pyroptosis, a programmed cell death process, is vital for the immune response against
microbial infections and internal danger signals. Recent studies have highlighted the …

Sepsis, a systemic inflammatory response triggered by infection, has a considerably high
mortality rate. However, effective prevention and intervention measures against sepsis …

Background: Innate immune cells play a crucial role in responding to microbial infections,
but their improper activation can also drive inflammatory disease. For this reason, their …

The precise control of interferon (IFN) production is indispensable for the host to eliminate
invading viruses and maintain a homeostatic state. In mammals, stimulator of interferon …