Pseudomonas aeruginosa ventricular assist device infections: findings from ineffective phage therapies in five cases

S Aslam, D Roach, MP Nikolich, B Biswas… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Left ventricular assist devices (LVAD) are increasingly used for management of heart failure;
infection remains a frequent complication. Phage therapy has been successful in a variety of …

First‐in‐human application of double‐stranded RNA bacteriophage in the treatment of pulmonary Pseudomonas aeruginosa infection

L Li, Q Zhong, Y Zhao, J Bao, B Liu… - Microbial …, 2023 - Wiley Online Library
A double‐stranded RNA (dsRNA) phage phiYY is able to kill a pyomelanin‐producing
Pseudomonas aeruginosa strain, which was isolated from a 40‐year‐old man with interstitial …

“Two is better than one”: The multifactorial nature of phage-antibiotic combinatorial treatments against ESKAPE-induced infections

GBN Fungo, JCW Uy, KLJ Porciuncula… - Phage, 2023 - liebertpub.com
Phage-antibiotic synergy (PAS) has been extensively explored over the past decade, with
the aim of developing more effective treatments against multidrug-resistant organisms …

Ciprofloxacin in combination with bacteriophage cocktails against multi-drug resistant Pseudomonas aeruginosa in ex vivo simulated endocardial vegetation models

A El Ghali, K Stamper, AJ Kunz Coyne… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Pseudomonas aeruginosa-associated infective endocarditis represents difficult-to-treat,
deep-seated infections. Phage-antibiotic combinations have shown to eradicate multi-drug …

Practical assessment of an interdisciplinary bacteriophage delivery pipeline for personalized therapy of gram-negative bacterial infections

S Würstle, J Stender, JA Hammerl, K Vogele, K Rothe… - Pharmaceuticals, 2022 - mdpi.com
Despite numerous advances in personalized phage therapy, smooth logistics are
challenging, particularly for multidrug-resistant Gram-negative bacterial infections requiring …

Steno‐sphere: Navigating the enigmatic world of emerging multidrug‐resistant Stenotrophomonas maltophilia

AJ Kunz Coyne, S Herbin, K Caniff… - … : The Journal of Human …, 2023 - Wiley Online Library
Stenotrophomonas maltophilia is an opportunistic pathogen and frequent cause of serious
nosocomial infections. Patient populations at greatest risk for these infections include the …

The application of adaptively evolved thermostable bacteriophage ΦYMFM0293 to control Salmonella spp. in poultry skin

J Lee, D Kim, M Kim - Food Research International, 2023 - Elsevier
Bacteriophages, bacterial viruses, are now being re-highlighted as one of the promising
alternative antimicrobial agents to control bacterial pathogens in various fields, including the …

Synergistic bactericidal effects of phage-enhanced antibiotic therapy against MRSA biofilms

AJ Kunz Coyne, K Stamper, C Bleick… - Microbiology …, 2024 - Am Soc Microbiol
Methicillin-resistant Staphylococcus aureus (MRSA) causes biofilm-related medical device
infections. Phage-antibiotic combinations offer potential therapy due to proven in vitro …

[HTML][HTML] Rapid hydrogel-based phage susceptibility test for pathogenic bacteria

S Patpatia, E Schaedig, A Dirks, L Paasonen… - Frontiers in Cellular …, 2022 - frontiersin.org
Phage therapy is one alternative to cure infections caused by antibiotic resistant bacteria.
Due to the narrow host range of phages, hundreds to thousands of phages are required to …

A mechanism-based pathway toward administering highly active N-phage cocktails

NM Smith, TD Nguyen, WH Chin, JT Sanborn… - Frontiers in …, 2023 - frontiersin.org
Bacteriophage (phage) therapy is being explored as a possible response to the
antimicrobial resistance public health emergency. Administering a mixture of different phage …