Interferon-α (IFNα) and IFNβ, collectively known as type I IFNs, are the major effector
cytokines of the host immune response against viral infections. However, the production of …

Interferon-gamma (IFNγ) is a central regulator of the immune response and signals via the
Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) …

Alterations to the tumor microenvironment following localized irradiation may influence the
effectiveness of subsequent immunotherapy. The objective of this study was to determine …

The immunoproteasome plays a key role in generation of HLA peptides for T cell-mediated
immunity. Integrative genomic and proteomic analysis of non-small cell lung carcinoma …

During viral infection, proper regulation of immune responses is necessary to ensure
successful viral clearance with minimal host tissue damage. Proteasomes play a crucial role …

The first STAT family member, STAT1, is an essential component of interferon (IFN)-
signaling, which mediates several cellular functions in response to stimulation by cytokines …

In the late 1980s and early 1990s, the hunt for a transporter molecule ostensibly responsible
for the translocation of peptides across the endoplasmic reticulum (ER) membrane yielded …

Downstream of cytokine or growth factor receptors, STAT3 counteracts inflammation and
promotes cell survival/proliferation and immune tolerance while STAT1 inhibits proliferation …

Triple-negative breast cancer (TNBC) is a heterogeneous subtype with varying disease
outcomes. Tumor-infiltrating lymphocytes (TILs) are frequent in TNBC and have been shown …

Atherosclerosis is a chronic inflammatory disease of the vasculature with lesions developing
in the arterial wall, frequently in the coronary and carotid arteries. The interaction between …