Fungal infections include a wide range of opportunistic and invasive diseases. Two of four
major fatal diseases in patients with human immunodeficiency virus (HIV) infection are …

Highlights•Candidalysin is the first peptide toxin identified in any human fungal
pathogen.•Epithelial cells identify invasive C. albicans by detecting Candidalysin …

Mucosa protects the body against external pathogen invasion. However, pathogen colonies
on the mucosa can invade the mucosa when the immunosurveillance is compromised …

Candida bloodstream infections remain the most frequent life-threatening fungal disease,
with Candida albicans accounting for 70% to 80% of the Candida isolates recovered from …

Recurrent vulvovaginal infections (RVVI), a devastating group of mucosal infection, are
severely affecting women's quality of life. Our understanding of the vaginal defense …

The tremendous diversity in microbial species that colonise the mucosal surfaces of the
human body is only now beginning to be fully appreciated. Distinguishing between the …

Extracellular vesicles have an important function in cellular communication. Here, we show
that human and mouse monocytes release TGF-β1-transporting vesicles in response to the …

Upon systemic infection with human pathogenic yeast Candida albicans (C. albicans),
human monocytes and polymorph nuclear neutrophilic granulocytes are the first immune …

Because of the growing numbers of immunocompromised patients, the incidence of life-
threatening fungal infections caused by Candida albicans and Aspergillus fumigatus is …

Sepsis is a major health problem all over the world. Despite its existence since the time of
Hippocrates (470 BC), sepsis is still a serious medical problem for physicians working in …