Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …

For more than 40 years, the epipodophyllotoxin drug etoposide is prescribed to treat cancer.
This semi-synthetic compound remains extensively used to treat advanced small-cell lung …

A global pandemic has erupted as a result of the new brand coronavirus, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic has been consociated …

Background: We aimed to establish an acute treatment protocol to increase serum vitamin D,
evaluate the effectiveness of vitamin D3 supplementation, and reveal the potential …

Abstract Interleukin (IL)-18 is a member of the IL-1 family of cytokines with pleiotropic and
potent pro-inflammatory activities that are tightly controlled at the level of production and in …

Severe acute respiratory syndrome coronovirus-2 (SARS-CoV-2) is the cause of the
coronavirus disease 2019 (COVID-19) pandemic. Vaccination is considered the core …

The risk of severe COVID-19 increases with age as older patients are at highest risk. Thus,
there is an urgent need to identify how severe acute respiratory syndrome coronavirus 2 …

Finding cytokine storm initiator factors associated with uncontrolled inflammatory immune
response is necessary in COVID-19 patients. The aim was the identification of Fas/Fas …

Viral infections can promote cytokine storm and multiorgan failure in individuals with an
underlying immunosuppression or specific genetic background. Hyperinflammatory states …

The current SARS-CoV-2 pandemic has emerged as an international challenge with strong
medical and socioeconomic impact. The spectrum of clinical manifestations of SARS-CoV-2 …