[HTML][HTML] SARS-CoV-2, COVID-19 and the aging immune system

JM Bartleson, D Radenkovic, AJ Covarrubias… - Nature aging, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic is a global health threat with
particular risk for severe disease and death in older adults and in adults with age-related …

[HTML][HTML] The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

MF Osuchowski, MS Winkler, T Skirecki… - The Lancet …, 2021 - thelancet.com
The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …

Interleukin-6 receptor antagonists in critically ill patients with Covid-19–preliminary report

Remap-Cap Investigators, AC Gordon, PR Mouncey… - Medrxiv, 2021 - medrxiv.org
Background The efficacy of interleukin-6 receptor antagonists in critically ill patients with
coronavirus disease 2019 (Covid-19) is unclear. Methods We evaluated tocilizumab and …

[HTML][HTML] Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses—are we our own worst enemy?

LYR Wong, S Perlman - Nature Reviews Immunology, 2022 - nature.com
Human coronaviruses cause a wide spectrum of disease, ranging from mild common colds
to acute respiratory distress syndrome and death. Three highly pathogenic human …

[HTML][HTML] Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?

V Bajaj, N Gadi, AP Spihlman, SC Wu, CH Choi… - Frontiers in …, 2021 - frontiersin.org
The novel coronavirus severe acute respiratory syndrome coronavirus 2 causing the
Coronavirus disease (COVID-19) pandemic has ravaged the world with over 72 million total …

Pregnancy and COVID-19

EAN Wastnedge, RM Reynolds… - Physiological …, 2021 - journals.physiology.org
There are many unknowns for pregnant women during the coronavirus disease 2019
(COVID-19) pandemic. Clinical experience of pregnancies complicated with infection by …

[HTML][HTML] A systematic review of SARS-CoV-2 vaccine candidates

Y Dong, T Dai, Y Wei, L Zhang, M Zheng… - Signal transduction and …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging virus that is
highly pathogenic and has caused the recent worldwide pandemic officially named …

[HTML][HTML] Immunological considerations for COVID-19 vaccine strategies

M Jeyanathan, S Afkhami, F Smaill, MS Miller… - Nature Reviews …, 2020 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to …

[HTML][HTML] Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection

L Townsend, AH Dyer, K Jones, J Dunne, A Mooney… - PloS one, 2020 - journals.plos.org
Fatigue is a common symptom in those presenting with symptomatic COVID-19 infection.
However, it is unknown if COVID-19 results in persistent fatigue in those recovered from …

[HTML][HTML] T cell responses in patients with COVID-19

Z Chen, E John Wherry - Nature Reviews Immunology, 2020 - nature.com
The role of T cells in the resolution or exacerbation of COVID-19, as well as their potential to
provide long-term protection from reinfection with SARS-CoV-2, remains debated …