[HTML][HTML] Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling

HM Jeon, JY Kim, HJ Cho, WJ Lee, D Nguyen, SS Kim… - Cancer cell, 2023 - cell.com
Radiation therapy (RT) provides therapeutic benefits for patients with glioblastoma (GBM),
but inevitably induces poorly understood global changes in GBM and its microenvironment …

[HTML][HTML] Microvascular thrombosis as a critical factor in severe COVID-19

PP Wadowski, B Panzer, A Józkowicz… - International Journal of …, 2023 - mdpi.com
Platelet–endothelial interactions have a critical role in microcirculatory function, which
maintains tissue homeostasis. The subtle equilibrium between platelets and the vessel wall …

Tissue factor binds to and inhibits interferon-α receptor 1 signaling

J Manoharan, R Rana, G Kuenze, D Gupta, A Elwakiel… - Immunity, 2024 - cell.com
Tissue factor (TF), which is a member of the cytokine receptor family, promotes coagulation
and coagulation-dependent inflammation. TF also exerts protective effects through unknown …

[HTML][HTML] Exploring the Pathophysiology of Long COVID: The Central Role of Low-Grade Inflammation and Multisystem Involvement

E Gusev, A Sarapultsev - International Journal of Molecular Sciences, 2024 - mdpi.com
Long COVID (LC), also referred to as Post COVID-19 Condition, Post-Acute Sequelae of
SARS-CoV-2 Infection (PASC), and other terms, represents a complex multisystem disease …

[HTML][HTML] Exploring the mechanism of chuanxiong rhizoma against thrombosis based on network pharmacology, molecular docking and experimental verification

S He, X He, S Pan, W Jiang - Molecules, 2023 - mdpi.com
Chuanxiong rhizoma (CX) has been utilized for centuries as a traditional herb to treat blood
stasis syndromes. However, the pharmacological mechanisms are still not completely …

Women With a History of Preeclampsia Exhibit Accelerated Aging and Unfavorable Profiles of Senescence Markers

S Suvakov, LE Vaughan, S Parashuram… - …, 2024 - Am Heart Assoc
BACKGROUND: Senescence, a mechanism of cellular aging, which is characterized by
irreversible proliferation arrest and a proinflammatory secretory phenotype, has been …

[HTML][HTML] On frailty and accelerated aging during SARS-Cov-2: senescence

U Müller-Werdan, MC Polidori, A Simm - Aging Clinical and Experimental …, 2023 - Springer
The COVID-19 pandemic is a burden for the worldwide healthcare systems. Whereas a clear
age-dependent mortality can be observed, especially multimorbid and frail persons are at an …

A bronchiole-on-a-chip and a stretching system for studying human disease model of asthma attack

CH Sun, KY Lee, YF Chan, SC Ho, CY Liu… - Sensors and Actuators B …, 2024 - Elsevier
Asthma is an important public health issue in developed and developing countries, with a
prevalence of 300 million worldwide. It is a heterogeneous disease characterized by chronic …

Monocyte-Mediated Thrombosis Linked to Circulating Tissue Factor and Immune Paralysis in COVID-19

SN Goonewardena, Q Chen, AM Tate… - … and Vascular Biology, 2024 - Am Heart Assoc
BACKGROUND: SARS-CoV-2 infections cause COVID-19 and are associated with
inflammation, coagulopathy, and high incidence of thrombosis. Myeloid cells help …

Multi-omics profiling reveals phenotypic and functional heterogeneity of neutrophils in COVID-19

L Zhang, H Nishi, K Kinoshita - International Journal of Molecular …, 2024 - mdpi.com
Accumulating evidence has revealed unexpected phenotypic heterogeneity and diverse
functions of neutrophils in several diseases. Coronavirus disease (COVID-19) can alter the …