Malaria vaccines: from the past towards the mRNA vaccine era

ME Tsoumani, C Voyiatzaki, A Efstathiou - Vaccines, 2023 - mdpi.com
Plasmodium spp. is the etiological agent of malaria, a life-threatening parasitic disease
transmitted by infected mosquitoes. Malaria remains a major global health challenge …

Virus-like particles derived from bacteriophage MS2 as antigen scaffolds and RNA protective shells

A Naskalska, JG Heddle - Nanomedicine, 2024 - Taylor & Francis
The versatile potential of bacteriophage MS2-derived virus-like particles (VLPs) in medical
biotechnology has been extensively studied during the last 30 years. Since the first reports …

Safety and immunogenicity of BK-SE36/CpG malaria vaccine in healthy Burkinabe adults and children: A phase 1b randomised, controlled, double-blinded, age de …

A Ouédraogo, EC Bougouma, NMQ Palacpac… - Frontiers in …, 2023 - frontiersin.org
Background BK-SE36/CpG is a recombinant blood-stage malaria vaccine candidate based
on the N-terminal Plasmodium falciparum serine repeat antigen5 (SE36), adsorbed to …

Evaluation of 4-aminoquinoline hydrazone analogues as potential leads for drug-resistant malaria

RN Magwaza, M Abubaker, B Hussain, M Haley… - Molecules, 2023 - mdpi.com
The emergence of resistance to first-line antimalarial drugs calls for the development of new
therapies for drug-resistant malaria. The efficacy of quinoline-based antimalarial drugs has …

Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain

VO Gawriljuk, AS Godoy, R Oerlemans… - Nature …, 2024 - nature.com
Plasmodium falciparum is the main causative agent of malaria, a deadly disease that mainly
affects children under five years old. Artemisinin-based combination therapies have been …

Evaluating the genetic diversity of the Plasmodium vivax siap2 locus: A promising candidate for an effective malaria vaccine?

SE Plata-Pineda, LX Cárdenas-Munévar… - Acta Tropica, 2024 - Elsevier
Malaria is the deadliest parasitic disease in the world. Traditional control measures have
become less effective; hence, there is a need to explore alternative strategies, such as …

Leveraging malaria vaccines and mRNA technology to tackle the global inequity in pharmaceutical research and production towards disease elimination

F Amimo - Malaria Journal, 2024 - Springer
Malaria vaccine introduction in endemic countries is a game-changing milestone in the fight
against the disease. This article examines the inequity in the global pharmaceutical …

Quest for malaria management using natural remedies

QT Ain, N Saleem, N Munawar, R Nawaz… - Frontiers in …, 2024 - frontiersin.org
Malaria, transmitted through the bite of a Plasmodium-infected Anopheles mosquito,
remains a significant global health concern. This review examines the complex life cycle of …

Assessing the relationship between malaria incidence levels and meteorological factors using cluster-integrated regression

M Amadi, KKW Erandi - BMC Infectious Diseases, 2024 - Springer
This paper introduces a novel approach to modeling malaria incidence in Nigeria by
integrating clustering strategies with regression modeling and leveraging meteorological …

Microalgae‐made human vaccines and therapeutics: A decade of advances

E Trujillo, E Monreal‐Escalante… - Biotechnology …, 2024 - Wiley Online Library
Microalgal emergence is a promising platform with two‐decade historical background for
producing vaccines and biopharmaceuticals. During that period, microalgal‐based vaccines …