Decoding DNA, RNA and peptides with quantum tunnelling

M Di Ventra, M Taniguchi - Nature nanotechnology, 2016 - nature.com
Drugs and treatments could be precisely tailored to an individual patient by extracting their
cellular-and molecular-level information. For this approach to be feasible on a global scale …

[图书][B] Kernel methods in computational biology

B Schölkopf, K Tsuda, JP Vert - 2004 - books.google.com
A detailed overview of current research in kernel methods and their application to
computational biology. Modern machine learning techniques are proving to be extremely …

Spectral biclustering of microarray data: coclustering genes and conditions

Y Kluger, R Basri, JT Chang, M Gerstein - Genome research, 2003 - genome.cshlp.org
Global analyses of RNA expression levels are useful for classifying genes and overall
phenotypes. Often these classification problems are linked, and one wants to find “marker …

Landslide susceptibility mapping based on support vector machine: a case study on natural slopes of Hong Kong, China

X Yao, LG Tham, FC Dai - Geomorphology, 2008 - Elsevier
The Support Vector Machine (SVM) is an increasingly popular learning procedure based on
statistical learning theory, and involves a training phase in which the model is trained by a …

Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research

A Scalbert, L Brennan, O Fiehn, T Hankemeier… - Metabolomics, 2009 - Springer
Mass spectrometry (MS) techniques, because of their sensitivity and selectivity, have
become methods of choice to characterize the human metabolome and MS-based …

Drug design by machine learning: support vector machines for pharmaceutical data analysis

R Burbidge, M Trotter, B Buxton, S Holden - Computers & chemistry, 2001 - Elsevier
We show that the support vector machine (SVM) classification algorithm, a recent
development from the machine learning community, proves its potential for structure–activity …

A comprehensive evaluation of multicategory classification methods for microarray gene expression cancer diagnosis

A Statnikov, CF Aliferis, I Tsamardinos, D Hardin… - …, 2005 - academic.oup.com
Motivation: Cancer diagnosis is one of the most important emerging clinical applications of
gene expression microarray technology. We are seeking to develop a computer system for …

TSVR: an efficient twin support vector machine for regression

X Peng - Neural Networks, 2010 - Elsevier
The learning speed of classical Support Vector Regression (SVR) is low, since it is
constructed based on the minimization of a convex quadratic function subject to the pair …

[图书][B] Evolving fuzzy systems-methodologies, advanced concepts and applications

E Lughofer - 2011 - Springer
In today's industrial systems, economic markets, life and health-care sciences fuzzy systems
play an important role in many application scenarios such as system identification, fault …

Genetical genomics: the added value from segregation

RC Jansen, JP Nap - TRENDS in Genetics, 2001 - cell.com
The recent successes of genome-wide expression profiling in biology tend to overlook the
power of genetics. We here propose a merger of genomics and genetics into 'genetical …