[HTML][HTML] Disease-drug and drug-drug interaction in COVID-19: Risk and assessment

D Kumar, N Trivedi - Biomedicine & Pharmacotherapy, 2021 - Elsevier
COVID-19 is announced as a global pandemic in 2020. Its mortality and morbidity rate are
rapidly increasing, with limited medications. The emergent outbreak of COVID-19 prompted …

Pleiotropic effects of tetracyclines in the management of COVID-19: emerging perspectives

HM Al-Kuraishy, AI Al-Gareeb, M Alqarni… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is a global infectious disease caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Approximately 15% of severe …

A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder

AR Sarohan, M Kızıl, AÇ İnkaya, S Mahmud, M Akram… - Cellular signalling, 2021 - Elsevier
The SARS-CoV-2 virus has caused a worldwide COVID-19 pandemic. In less than a year
and a half, more than 200 million people have been infected and more than four million …

Prenol, but not vitamin C, of fruit binds to SARS-CoV-2 spike S1 to inhibit viral entry: Implications for COVID-19

RK Paidi, M Jana, S Raha, RK Mishra… - The Journal of …, 2023 - journals.aai.org
Fruit consumption may be beneficial for fighting infection. Although vitamin C is the celebrity
component of fruit, its role in COVID-19 is unclear. Because spike S1 of SARS-CoV-2 binds …

[HTML][HTML] Development of a physiomimetic model of acute respiratory distress syndrome by using ECM hydrogels and organ-on-a-chip devices

E Marhuenda, A Villarino, M Narciso… - Frontiers in …, 2022 - frontiersin.org
Acute Respiratory Distress Syndrome is one of the more common fatal complications in
COVID-19, characterized by a highly aberrant inflammatory response. Pre-clinical models to …

[HTML][HTML] Drug repositioning with GraphSAGE and clustering constraints based on drug and disease networks

Y Zhang, X Lei, Y Pan, FX Wu - Frontiers in Pharmacology, 2022 - frontiersin.org
The understanding of therapeutic properties is important in drug repositioning and drug
discovery. However, chemical or clinical trials are expensive and inefficient to characterize …

[HTML][HTML] Protective effect of melatonin administration against SARS-CoV-2 infection: A systematic review

A Molina-Carballo, R Palacios-López… - Current issues in …, 2022 - mdpi.com
Introduction: according to the World Health Organization (WHO), COVID-19 is an infectious
disease caused by the SARS-CoV-2 virus, responsible for an increasing number of cases …

Spiroindole-containing compounds bearing phosphonate group of potential Mpro-SARS-CoV-2 inhibitory properties

MS Bekheit, SS Panda, BM Kariuki… - European Journal of …, 2023 - Elsevier
Abstract Microwave-assisted reaction of 3, 5-bis ((E)-ylidene)-1-phosphonate-4-piperidones
3a‒g with azomethine ylide (produced through interaction of isatins 4 and sarcosine 5) …

Indole-based compounds as potential drug candidates for SARS-CoV-2

AS Girgis, SS Panda, BM Kariuki, MS Bekheit… - Molecules, 2023 - mdpi.com
The COVID-19 pandemic has posed a significant threat to society in recent times,
endangering human health, life, and economic well-being. The disease quickly spreads due …

[HTML][HTML] Evaluation of SARS-CoV-2-neutralizing nanobody using virus receptor binding domain-administered model mice

S Liu, G Li, L Ding, J Ding, Q Zhang, D Li, X Hou… - Research, 2022 - spj.science.org
Due to the rapid spread of coronavirus disease 2019 (COVID-19), there is an urgent
requirement for the development of additional diagnostic tools for further analysis of the …