Many effective drugs for metastatic and/or advanced-stage cancers have been developed
over the past decade, although the evolution of resistance remains the major barrier to …

With the burgeoning use of immune-based treatments for cancer, never has there been a
greater need to understand the tumour microenvironment within which immune cells …

Adaptive therapy is a dynamic cancer treatment protocol that updates (or 'adapts') treatment
decisions in anticipation of evolving tumor dynamics. This broad term encompasses many …

A new ecologically inspired paradigm in cancer treatment known as “adaptive therapy”
capitalizes on competitive interactions between drug-sensitive and drug-resistant subclones …

Recent studies have shown that a strategy aiming for containment, not elimination, can
control tumour burden more effectively in vitro, in mouse models and in the clinic. These …

Evolutionary game theory mathematically conceptualizes and analyzes biological
interactions where one's fitness not only depends on one's own traits, but also on the traits of …

Intermittent androgen deprivation therapy (IADT) is an attractive treatment for biochemically
recurrent prostate cancer (PCa), whereby cycling treatment on and off can reduce …

Purpose: Integration of evolutionary dynamics into systemic therapy for metastatic cancers
can prolong tumor control compared with standard maximum tolerated dose (MTD) …

Simple Summary Tumors are composed of different cancer cells with varying degrees of
treatment resistance, which compete for a shared resource. Adaptive therapy is an evolution …

In the absence of curative therapies, treatment of metastatic castrate-resistant prostate
cancer (mCRPC) using currently available drugs can be improved by integrating …