Advances in pathogenesis and therapeutic strategies for osteoporosis

S Song, Y Guo, Y Yang, D Fu - Pharmacology & therapeutics, 2022 - Elsevier
Osteoporosis, is the most common bone disorder worldwide characterized by low bone
mineral density, leaving affected bones vulnerable to fracture. Bone homeostasis depends …

A review of colorectal cancer in terms of epidemiology, risk factors, development, symptoms and diagnosis

T Sawicki, M Ruszkowska, A Danielewicz… - Cancers, 2021 - mdpi.com
Simple Summary According to the available data, colorectal cancer (CRC) is one of the most
common malignant neoplasms. Depending on the location, type of cancer or gender, it is …

Microbiota medicine: towards clinical revolution

P Gebrayel, C Nicco, S Al Khodor, J Bilinski… - Journal of translational …, 2022 - Springer
The human gastrointestinal tract is inhabited by the largest microbial community within the
human body consisting of trillions of microbes called gut microbiota. The normal flora is the …

The Many Faces of Enterococcus spp.—Commensal, Probiotic and Opportunistic Pathogen

B Krawczyk, P Wityk, M Gałęcka, M Michalik - Microorganisms, 2021 - mdpi.com
Enterococcus spp. are Gram-positive, facultative, anaerobic cocci, which are found in the
intestinal flora and, less frequently, in the vagina or mouth. Enterococcus faecalis and …

Role of tumor microenvironment in cancer progression and therapeutic strategy

Q Wang, X Shao, Y Zhang, M Zhu, FXC Wang… - Cancer …, 2023 - Wiley Online Library
Cancer is now considered a tumor microenvironment (TME) disease, although it was
originally thought to be a cell and gene expression disorder. Over the past 20 years …

Oxidative stress, inflammation and colorectal cancer: an overview

A Bardelčíková, J Šoltys, J Mojžiš - Antioxidants, 2023 - mdpi.com
Colorectal cancer (CRC) represents the second leading cause of cancer-related deaths
worldwide. The pathogenesis of CRC is a complex multistep process. Among other factors …

Potential role of the gut microbiome in colorectal cancer progression

J Kim, HK Lee - Frontiers in immunology, 2022 - frontiersin.org
An increasing number of studies have revealed that the progression of colorectal cancer
(CRC) is related to gut microbiome composition. Under normal conditions, the gut …

New insights into natural products that target the gut microbiota: Effects on the prevention and treatment of colorectal cancer

L Lu, J Dong, Y Liu, Y Qian, G Zhang, W Zhou… - Frontiers in …, 2022 - frontiersin.org
Colorectal cancer (CRC) is one of the most common malignant carcinomas. CRC is
characterized by asymptomatic onset, and most patients are already in the middle and …

Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice

JL Drewes, J Chen, NO Markham, RJ Knippel… - Cancer discovery, 2022 - AACR
Defining the complex role of the microbiome in colorectal cancer and the discovery of novel,
protumorigenic microbes are areas of active investigation. In the present study, culturing and …

Participation of short-chain fatty acids and their receptors in gut inflammation and colon cancer

MD Carretta, J Quiroga, R López, MA Hidalgo… - Frontiers in …, 2021 - frontiersin.org
Short-chain fatty acids (SCFAs) are the main metabolites produced by the bacterial
fermentation of dietary fiber, and they play a critical role in the maintenance of intestinal …