Transposable elements (TEs) are mobile DNA elements that comprise almost 50% of
mammalian genomic sequence. TEs are capable of making additional copies of themselves …

Mammalian fertilization begins with the fusion of two specialized gametes, followed by major
epigenetic remodeling leading to the formation of a totipotent embryo. During the …

Translational regulation plays a critical role during the oocyte-to-embryo transition (OET)
and zygotic genome activation (ZGA). Here, we integrated ultra-low-input ribosome profiling …

Chromosome conformation capture data, particularly from high-throughput approaches such
as Hi-C, are typically very complex to analyse. Existing analysis tools are often single …

Maternal mRNA clearance is an essential process that occurs during maternal-to-zygotic
transition (MZT). However, the dynamics, functional importance, and pathological relevance …

Abstract Poly (A)-tail-mediated post-transcriptional regulation of maternal mRNAs is vital in
the oocyte-to-embryo transition (OET). Nothing is known about poly (A) tail dynamics during …

Reprogramming of H3K9me3-dependent heterochromatin is required for early development.
How H3K9me3 is involved in early human development remains, however, largely unclear …

Transposable elements (TEs) are major contributors of genetic material in mammalian
genomes. These often include binding sites for architectural proteins, including the …

It remains poorly understood about the regulation of gene and transposon transcription
during human early embryogenesis. Here, we report that broad H3K27ac domains are …

Extrachromosomal circular DNA (eccDNA) is common in somatic tissue, but its existence
and effects in the human germline are unexplored. We used microscopy, long-read DNA …