TADeus2: a web server facilitating the clinical diagnosis by pathogenicity assessment of structural variations disarranging 3D chromatin structure
B Poszewiecka, VM Pienkowski… - Nucleic Acids …, 2022 - academic.oup.com
In recent years great progress has been made in identification of structural variants (SV) in
the human genome. However, the interpretation of SVs, especially located in non-coding …
the human genome. However, the interpretation of SVs, especially located in non-coding …
Stressful start causes chromosome errors in human embryos
T Cavazza, M Schuh - 2022 - nature.com
Stressful start causes chromosome errors in human embryos Skip to main content Thank you
for visiting nature.com. You are using a browser version with limited support for CSS. To obtain …
for visiting nature.com. You are using a browser version with limited support for CSS. To obtain …
Dissecting the molecular features of bovine-arrested eight-cell embryos using single-cell multi-omics sequencing
J Zhang, Q Lyu, J Li, Z Ma, R Yang, X Yin… - Biology of …, 2023 - academic.oup.com
The regulation of mammalian early-embryonic development is a complex, coordinated
process that involves widespread transcriptomic and epigenetic remodeling. The main …
process that involves widespread transcriptomic and epigenetic remodeling. The main …
A tremendous reorganization journey for the 3D chromatin structure from gametes to embryos
Z Chen, X Chen - Genes, 2022 - mdpi.com
The 3D chromatin structure within the nucleus is important for gene expression regulation
and correct developmental programs. Recently, the rapid development of low-input …
and correct developmental programs. Recently, the rapid development of low-input …
Advances in studying human gametogenesis and embryonic development in China
Reproductive medicine in China has developed rapidly since 1988 due to support from the
government and scientific exploration. However, the success rate of assisted reproduction …
government and scientific exploration. However, the success rate of assisted reproduction …
TAMC: A deep-learning approach to predict motif-centric transcriptional factor binding activity based on ATAC-seq profile
Determining transcriptional factor binding sites (TFBSs) is critical for understanding the
molecular mechanisms regulating gene expression in different biological conditions …
molecular mechanisms regulating gene expression in different biological conditions …
Omne vivum ex ovo: the oocyte reprogramming and remodeling activities
In brief Understanding the establishment of post-fertilization totipotency has broad
implications for modern biotechnologies. This review summarizes the current knowledge of …
implications for modern biotechnologies. This review summarizes the current knowledge of …
2-cell-like cells: an avenue for improving SCNT efficiency
B Fu, H Ma, D Liu - Biomolecules, 2022 - mdpi.com
After fertilization, the zygote genome undergoes dramatic structural reorganization to ensure
the establishment of totipotency, and then the totipotent potential of the zygote or 2-cell …
the establishment of totipotency, and then the totipotent potential of the zygote or 2-cell …
Epigenomic dynamics of early Xenopus Embryos
How the embryonic genome regulates accessibility to transcription factors is one of the
major questions in understanding the spatial and temporal dynamics of gene expression …
major questions in understanding the spatial and temporal dynamics of gene expression …
Causality in transcription and genome folding: insights from X inactivation
The spatial organization of genomes is becoming increasingly understood. In mammals,
where it is most investigated, this organization ties in with transcription, so an important …
where it is most investigated, this organization ties in with transcription, so an important …