Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk

LE Wroblewski, RM Peek Jr… - Clinical microbiology …, 2010 - Am Soc Microbiol
Helicobacter pylori is a gastric pathogen that colonizes approximately 50% of the world's
population. Infection with H. pylori causes chronic inflammation and significantly increases …

[HTML][HTML] Oxidative stress resulting from Helicobacter pylori infection contributes to gastric carcinogenesis

LD Butcher, G den Hartog, PB Ernst… - Cellular and molecular …, 2017 - Elsevier
Helicobacter pylori is a gram-negative, microaerophilic bacterium that infects the stomach
and can lead to, among other disorders, the development of gastric cancer. The inability of …

[HTML][HTML] Helicobacter pylori persistence: biology and disease

MJ Blaser, JC Atherton - The Journal of clinical investigation, 2004 - Am Soc Clin Investig
Helicobacter pylori are bacteria that have coevolved with humans to be transmitted from
person to person and to persistently colonize the stomach. Their population structure is a …

Persistent bacterial infections: the interface of the pathogen and the host immune system

DM Monack, A Mueller, S Falkow - Nature Reviews Microbiology, 2004 - nature.com
Persistent bacterial infections involving Mycobacterium tuberculosis, Salmonella enterica
serovar Typhi (S. typhi) and Helicobacter pylori pose significant public-health problems …

ppGpp conjures bacterial virulence

ZD Dalebroux, SL Svensson, EC Gaynor… - Microbiology and …, 2010 - Am Soc Microbiol
Like for all microbes, the goal of every pathogen is to survive and replicate. However, to
overcome the formidable defenses of their hosts, pathogens are also endowed with traits …

Helicobacter pylori VacA, a paradigm for toxin multifunctionality

TL Cover, SR Blanke - Nature Reviews Microbiology, 2005 - nature.com
Bacterial protein toxins alter eukaryotic cellular processes and enable bacteria to
successfully colonize their hosts. In recent years, there has been increased recognition that …

An Overview of Helicobacter pylori VacA Toxin Biology

NJ Foegeding, RR Caston, MS McClain, MD Ohi… - Toxins, 2016 - mdpi.com
The VacA toxin secreted by Helicobacter pylori enhances the ability of the bacteria to
colonize the stomach and contributes to the pathogenesis of gastric adenocarcinoma and …

Helicobacter pylori and Its Role in Gastric Cancer

VE Reyes - Microorganisms, 2023 - mdpi.com
Gastric cancer is a challenging public health concern worldwide and remains a leading
cause of cancer-related mortality. The primary risk factor implicated in gastric cancer …

Role of Innate Immunity in Helicobacter pylori-Induced Gastric Malignancy

RM Peek Jr, C Fiske, KT Wilson - Physiological reviews, 2010 - journals.physiology.org
Helicobacter pylori colonizes the majority of persons worldwide, and the ensuing gastric
inflammatory response is the strongest singular risk factor for peptic ulceration and gastric …

Helicobacter pylori VacA, a distinct toxin exerts diverse functionalities in numerous cells: An overview

N Chauhan, ACY Tay, BJ Marshall, U Jain - Helicobacter, 2019 - Wiley Online Library
Background Helicobacter pylori, gastric cancer‐causing bacteria, survive in their gastric
environment of more than 50% of the world population. The presence of H. pylori in the …