Bone tissue is continuously remodeled through the concerted actions of bone cells, which
include bone resorption by osteoclasts and bone formation by osteoblasts, whereas …

The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …

As the only cells definitively shown to degrade bone, osteoclasts are key mediators of
skeletal diseases including osteoporosis. Bone-forming osteoblasts, and hematopoietic and …

The adult skeleton regenerates by temporary cellular structures that comprise teams of
juxtaposed osteoclasts and osteoblasts and replace periodically old bone with new. A …

Tissue remodeling processes critically depend on the timely removal and remodeling of
preexisting collagen scaffolds. Nevertheless, many aspects related to the turnover of this …

Osteoporosis is defined as low bone mineral density associated with skeletal fractures
secondary to minimal or no trauma, most often involving the spine, the hip, and the forearm …

The hormone calcitonin (CT) is primarily known for its pharmacologic action as an inhibitor
of bone resorption, yet CT-deficient mice display increased bone formation. These findings …

MicroRNAs (miRNAs) play important roles in osteoclastogenesis and bone resorption.
However, no study has investigated the role of miRNA in postmenopausal osteoporosis …

Coupling is the process that links bone resorption to bone formation in a temporally and
spatially coordinated manner within the remodeling cycle. Several lines of evidence point to …

Eur J Clin Invest 2012; 42 (12): 1332–1341 Abstract Background Bone remodelling
maintains skeletal integrity by osteoclasts removing foci of damaged bone and osteoblasts …